Role of ischemia-modified albumin in clinical practice

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dc.contributor.authorErenler, Ali Kemal
dc.contributor.authorYardan, Türker
dc.contributor.authorKatı, Celal
dc.contributor.authorAltuntaş, Mehmet
dc.contributor.authorTüredi, Süleyman
dc.date.accessioned2019-05-13T08:57:14Z
dc.date.available2019-05-13T08:57:14Z
dc.date.issued2015
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractDifficulty in establishing a diagnosis of acute coronary syndrome (ACS) in the clinical setting has led researchers to investigate novel markers that show increased blood levels before the myocardial necrosis occurs. In ischemic conditions, some modifications occur in the amino acids located on the N-terminus of the human albumin molecule. Ischemia-modified albumin (IMA) is a marker formed after damage in the N-terminal region of albumin. The altered N-terminus can no longer bind transition metals, such as cobalt. The causes of the increases in IMA have been shown to be endothelial or extracellular hypoxia, acidosis, and free oxygen radicals. IMA, an early marker of ischemic disorders, is also a candidate marker for the detection of ACS. An assay measuring IMA might represent a promising marker for the identification of patients with myocardial ischemia. The aim of this study was to evaluate the clinical utility of IMA in the assessment of ACS as well as other medical disorders in light of the recent literature. © 2015 by De Gruyter.
dc.identifier.citationErenler, A. K., Yardan, T., Katı, C., Altuntaş, M., Türedi, S. (2015). Role of ischemia-modified albumin in clinical practice. LaboratoriumsMedizin, 39(4), 241-247.
dc.identifier.doi10.1515/labmed-2015-0038
dc.identifier.endpage247en_US
dc.identifier.issn0342-3026
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.1515/labmed-2015-0038
dc.identifier.urihttps://hdl.handle.net/11491/878
dc.identifier.volume39en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWalter de Gruyter GmbH
dc.relation.ispartofLaboratoriumsMedizin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcute Coronary Syndromeen_US
dc.subjectBiochemistryen_US
dc.subjectIschemia-Modified Albuminen_US
dc.titleRole of ischemia-modified albumin in clinical practice
dc.typeArticle

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