Determination of pKa values of some butyrophenones, their sensitive LC-UV analysis in pharmaceutical dosage forms and stress degradation behavior under ICH-recommended stress conditions
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Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, pKa values of some ionizable butyrophenones, namely, benperidol, droperidol, and haloperidol were determined using by the dependence of the retention factor on pH of the mobile phase. The effect of the mobile phase composition on the ionization constant was studied by measuring the pKa at different methanol-water mixtures, ranging between 50 and 65% (v/v) using an LC-UV method. Additionally, a simple, accurate, precise, and fully validated analytical method for the simultaneous and individual determination of benperidol, droperidol, and haloperidol in their dosage forms was developed. Butyrophenones were exposed to thermal, photolytic, hydrolytic, and oxidative stress conditions, and the stressed samples were detected by the proposed method. © 2013 Copyright Taylor and Francis Group, LLC.
Açıklama
Anahtar Kelimeler
Benperidol, Degradation, Droperidol, Haloperidol, Liquid Chromatography, PK A Values
Kaynak
Journal of Liquid Chromatography and Related Technologies
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
36
Sayı
7
Künye
Şanlı, S., Özkan, S. A., Güney, Z. (2013). Determination of pKa values of some butyrophenones, their sensitive LC-UV analysis in pharmaceutical dosage forms and stress degradation behavior under ICH-recommended stress conditions. Journal of Liquid Chromatography and Related Technologies, 36(7), 821-835.
