Determination of pKa values of some butyrophenones, their sensitive LC-UV analysis in pharmaceutical dosage forms and stress degradation behavior under ICH-recommended stress conditions

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dc.contributor.authorŞanlı, Senem
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.contributor.authorGüney, Zeynep
dc.date.accessioned2019-05-13T09:02:28Z
dc.date.available2019-05-13T09:02:28Z
dc.date.issued2013
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractIn this study, pKa values of some ionizable butyrophenones, namely, benperidol, droperidol, and haloperidol were determined using by the dependence of the retention factor on pH of the mobile phase. The effect of the mobile phase composition on the ionization constant was studied by measuring the pKa at different methanol-water mixtures, ranging between 50 and 65% (v/v) using an LC-UV method. Additionally, a simple, accurate, precise, and fully validated analytical method for the simultaneous and individual determination of benperidol, droperidol, and haloperidol in their dosage forms was developed. Butyrophenones were exposed to thermal, photolytic, hydrolytic, and oxidative stress conditions, and the stressed samples were detected by the proposed method. © 2013 Copyright Taylor and Francis Group, LLC.
dc.identifier.citationŞanlı, S., Özkan, S. A., Güney, Z. (2013). Determination of pKa values of some butyrophenones, their sensitive LC-UV analysis in pharmaceutical dosage forms and stress degradation behavior under ICH-recommended stress conditions. Journal of Liquid Chromatography and Related Technologies, 36(7), 821-835.
dc.identifier.doi10.1080/10826076.2012.678026
dc.identifier.endpage835en_US
dc.identifier.issn1082-6076
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage821en_US
dc.identifier.urihttps://doi.org/10.1080/10826076.2012.678026
dc.identifier.urihttps://hdl.handle.net/11491/1261
dc.identifier.volume36en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofJournal of Liquid Chromatography and Related Technologies
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBenperidolen_US
dc.subjectDegradationen_US
dc.subjectDroperidolen_US
dc.subjectHaloperidolen_US
dc.subjectLiquid Chromatographyen_US
dc.subjectPK A Valuesen_US
dc.titleDetermination of pKa values of some butyrophenones, their sensitive LC-UV analysis in pharmaceutical dosage forms and stress degradation behavior under ICH-recommended stress conditions
dc.typeArticle

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