Serum osteoprotegerin level is independently related to subclinical left atrial mechanical function in patients with hypertension and diabetes

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dc.authoridCetin, Mustafa / 0000-0001-6342-436X
dc.authoridKALAYCIOGLU, EZGI / 0000-0003-2122-1817
dc.authorwosidCetin, Mustafa / A-2919-2016
dc.authorwosidKALAYCIOGLU, EZGI / ABG-6777-2020
dc.contributor.authorKalaycioglu, Ezgi
dc.contributor.authorCetin, Mustafa
dc.contributor.authorCinier, Goksel
dc.contributor.authorKiris, Tuncay
dc.contributor.authorGokdeniz, Tayyar
dc.contributor.authorOzyildiz, Ali Gokhan
dc.contributor.authorDurmus, Ismet
dc.date.accessioned2021-11-01T15:06:12Z
dc.date.available2021-11-01T15:06:12Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractObjectives Previous studies showed that subclinical abnormal left atrial (LA) function could be diagnosed with LA speckle tracking evaluation long before chamber enlargement. Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor superfamily and was recently found to be an indicator for adverse cardiovascular outcomes and a risk factor for new onset atrial fibrillation. The authors hypothesized that OPG values could predict LA mechanical dysfunction and LA remodeling assessed by two-dimensional speckle tracking echocardiography (2D-STE) in patients with hypertension (HT) and diabetes mellitus (DM). Methods A single center study was conducted including consecutive patients presenting to the authors' outpatient clinic. Enrolled patients needed to have been treated for HT and DM for at least 1 year. Results The study included 80 patients (mean age, 57.5 +/- 8.3 years). Patients in the impaired LA strain group were older (p = 0.035), had lower low density lipoprotein (LDL) cholesterol (mg/dl) (p = 0.021), and higher OPG (pmol/l) (p = 0.004) values than patients in the normal LA strain group. Univariate logistic regression analysis demonstrated that age (p = 0.039), LDL cholesterol (mg/dl) (p = 0.025), and OPG (pmol/l) (p = 0.008) values were associated with impaired LA strain. Backward multivariate logistic regression analysis showed that LDL cholesterol (mg/dl) (OR: 0.982, CI 95% 0.964-0.999,p = 0.049) and OPG (pmol/l) (OR: 1.438, CI 95% 1.043-1.983,p = 0.027) were independently associated with impaired LA strain. Conclusion In hypertensive and diabetic patients, higher OPG values were associated with impaired LA function assessed by 2D-STE. In this high-risk patient group, serum OPG can be used as a risk predictor for LA mechanical dysfunction.
dc.identifier.doi10.1007/s00059-020-04939-7
dc.identifier.endpage284en_US
dc.identifier.issn0340-9937
dc.identifier.issn1615-6692
dc.identifier.issue3en_US
dc.identifier.pmid32462219
dc.identifier.scopus2-s2.0-85085499827
dc.identifier.scopusqualityQ3
dc.identifier.startpage277en_US
dc.identifier.urihttps://doi.org/10.1007/s00059-020-04939-7
dc.identifier.urihttps://hdl.handle.net/11491/7517
dc.identifier.volume46en_US
dc.identifier.wosWOS:000556232600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherUrban & Vogel
dc.relation.ispartofHerz
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAtrial fibrillationen_US
dc.subjectCholesterolen_US
dc.subjectLDLen_US
dc.subjectVascular systemen_US
dc.subjectLeft atriumen_US
dc.subjectTwo-dimensional speckle tracking echocardiographyen_US
dc.titleSerum osteoprotegerin level is independently related to subclinical left atrial mechanical function in patients with hypertension and diabetes
dc.typeArticle

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