Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: A systematic review and meta-analysis

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dc.contributor.authorTerrin, Gianluca
dc.contributor.authorConte, Francesca
dc.contributor.authorÖncel, Mehmet Yekta
dc.contributor.authorScipione, Antonella
dc.contributor.authorMcNamara, Patrick J.
dc.contributor.authorSimons, Sinno
dc.contributor.authorSinha, Rahul
dc.contributor.authorErdeve, Ömer
dc.contributor.authorTekgündüz, Kadir S.
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorKessel, Irena
dc.contributor.authorHammerman, Cathy
dc.contributor.authorNadir, E.
dc.contributor.authorYurttutan, Sadık
dc.contributor.authorJasani, Bonny
dc.contributor.authorAlan, Serdar
dc.contributor.authorManguso, Francesco
dc.contributor.authorDe Curtis, Mario
dc.date.accessioned2019-05-13T09:03:37Z
dc.date.available2019-05-13T09:03:37Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjectives We performed a systematic review and meta-analysis of all the available evidence to assess the efficacy and safety of paracetamol for the treatment of patent ductus arteriosus (PDA) in neonates, and to explore the effects of clinical variables on the risk of closure. Data source MEDLINE, Scopus and ISI Web of Knowledge databases, using the following medical subject headings and terms: paracetamol, acetaminophen and patent ductus arteriosus. Electronic and manual screening of conference abstracts from international meetings of relevant organisations. Manual search of the reference lists of all eligible articles. Study selection Studies comparing paracetamol versus ibuprofen, indomethacin, placebo or no intervention for the treatment of PDA. Data extraction Data regarding efficacy and safety were collected and analysed. Results Sixteen studies were included: 2 randomised controlled trials (RCTs) and 14 uncontrolled studies. Quality of selected studies is poor. A meta-analysis of RCTs does not demonstrate any difference in the risk of ductal closure (Mantel-Haenszel model, RR 1.07, 95% CI 0.87 to 1.33 and RR 1.03, 95% CI 0.92 to 1.16, after 3 and 6 days of treatment, respectively). Proportion meta-analysis of uncontrolled studies demonstrates a pooled ductal closure rate of 49% (95% CI 29% to 69%) and 76% (95% CI 61% to 88%) after 3 and 6 days of treatment with paracetamol, respectively. Safety profiles of paracetamol and ibuprofen are similar. Conclusions Efficacy and safety of paracetamol appear to be comparable with those of ibuprofen. These results should be interpreted with caution, taking into account the non-optimal quality of the studies analysed and the limited number of neonates treated with paracetamol so far.
dc.identifier.citationTerrin, G., Conte, F., Öncel, M. Y., Scipione, A., McNamara, P. J., Simons, S., I., Sinha, R., Erdeve, Ö. [et.al.]. (2016). Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis. Archives of Disease in Childhood-Fetal and Neonatal Edition, 101(2), F127-F136.
dc.identifier.doi10.1136/archdischild-2014-307312
dc.identifier.endpageF136en_US
dc.identifier.issn1359-2998
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpageF127en_US
dc.identifier.urihttps://doi.org/10.1136/archdischild-2014-307312
dc.identifier.urihttps://hdl.handle.net/11491/1503
dc.identifier.volume101en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.relation.ispartofArchives of Disease in Childhood: Fetal and Neonatal Edition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titleParacetamol for the treatment of patent ductus arteriosus in preterm neonates: A systematic review and meta-analysis
dc.typeArticle

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