Poly(vinyl alcohol)/(hyaluronic acid-g-kappa-carrageenan) hydrogel as antibiotic-releasing wound dressing

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dc.authoridÖzkahraman, Bengi / 0000-0003-1535-4381
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorBayrak, Gülşen
dc.contributor.authorKılıç Süloğlu, Aysun
dc.contributor.authorPerçin, Işık
dc.contributor.authorBoran, Filiz
dc.contributor.authorTamahkar, Emel
dc.contributor.authorBoran, Filiz
dc.date.accessioned2021-11-01T15:05:56Z
dc.date.available2021-11-01T15:05:56Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Polimer Malzeme Mühendisliği Bölümü
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü
dc.description.abstractThe aim of this research was to investigate the potential of ampicillin-loaded hydrogels based on polyvinyl alcohol (PVA), hyaluronic acid (HA) and kappa-carrageenan ((K)-Carr) as an antibiotic-releasing wound dressing. Firstly, the novel polymers (HA-g-(K)-Carr) were synthesized by grafting of HA onto (K)-Carr using 4-dimethylaminopyridine/1-(3-dimethylaminopyl)-3-ethyl-carbodiimide hydrochloride as catalyst system via esterification reaction. The characterization of the polymer structure was performed by Fourier transform infrared spectrum (FTIR), proton nuclear magnetic resonance and thermogravimetric analysis. Secondly, PVA/(HA-g-(K)-Carr) hydrogel with/without loading of ampicillin molecules was formed via freeze-thawing method since PVA/K-Carr and PVA/HA hydrogels were also fabricated as control groups. The hydrogels were subjected to characterizations with FTIR and X-ray diffractometer. PVA/(HA-g-(K)-Carr) hydrogel demonstrated the highest swelling amount and highest ampicillin release amount reaching an equilibrium value after 480 min rather than the other hydrogels. Also, PVA/(HA-g-(K)-Carr) hydrogel exhibited inhibition zone against Escherichia coli and Staphylococcus aureus and no cytotoxic effect for L929 cells. All the results showed that PVA/(HA-g-(K)-Carr) hydrogels are good candidates for wound dressing applications.
dc.description.sponsorshipHitit University Scientific and Technical Application and Research Centeren_US
dc.description.sponsorshipThe authors are grateful to the support of Hitit University Scientific and Technical Application and Research Center.en_US
dc.identifier.citationÖzbaş, Z., Özkahraman, B., Bayrak, G., Kılıç Süloğlu, A., Perçin, I., Boran, F., & Tamahkar, E. (2021). Poly (vinyl alcohol)/(hyaluronic acid-g-kappa-carrageenan) hydrogel as antibiotic-releasing wound dressing. Chemical Papers, 75(12), 6591-6600.
dc.identifier.doi10.1007/s11696-021-01824-3
dc.identifier.endpage6600en_US
dc.identifier.issn0366-6352
dc.identifier.issn2585-7290
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85113175691
dc.identifier.scopusqualityQ2
dc.identifier.startpage6591en_US
dc.identifier.urihttps://doi.org/10.1007/s11696-021-01824-3
dc.identifier.urihttps://hdl.handle.net/11491/7448
dc.identifier.volume75en_US
dc.identifier.wosWOS:000687255600004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖzkahraman, Bengi
dc.language.isoen
dc.publisherSpringer Int Publ Ag
dc.relation.ispartofChemical Papers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectKappa-Carrageenan ((K)-Carr)en_US
dc.subjectHyaluronic Aciden_US
dc.subjectWound Dressing With Antibiotic Releaseen_US
dc.subjectAntibacterial Activityen_US
dc.subjectCell Viabilityen_US
dc.titlePoly(vinyl alcohol)/(hyaluronic acid-g-kappa-carrageenan) hydrogel as antibiotic-releasing wound dressing
dc.typeArticle

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