Possible association between DNA repair gene variants and cannabis dependence in a Turkish cohort: a pilot study

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dc.authorid0000-0001-7639-1122
dc.contributor.authorPehlivan, Sacide
dc.contributor.authorYazıcı, Ahmet Bülent
dc.contributor.authorAydın, Nazan
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorKurnaz, Selin
dc.contributor.authorÖngel Atar, Ayça
dc.contributor.authorSever, Ülgen
dc.contributor.authorKıncır, Zeliha
dc.contributor.authorPehlivan, Mustafa
dc.contributor.authorÇetinay Aydın, Pınar
dc.date.accessioned2019-05-13T09:07:59Z
dc.date.available2019-05-13T09:07:59Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractOBJECTIVE: Substance use disorder (SUD) has important effects on health and well-being. It is well known that genetic factors play a role in SUD. The purpose of this research was to investigate whether functional variants of DNA repair genes might be a risk factor for cannabis and/or synthetic cannabis dependence in a Turkish cohort. METHODS: In total, 131 patients with cannabis and/or synthetic dependence and 70 healthy controls were included in this case–control study. XRCC1 codon 399 (rs25487) and XRCC4 G1394 T (rs6869366), and XPD (rs13181) variants were determined by the polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). RESULTS: The XRCC1 rs25487 GG genotype and G allele were significantly lower in patients compared to controls (p = 0.005; p = 0.002, respectively). XRCC4 rs6869366 TT genotype and T allele were more common in patients compared to controls (p = 0.001, p = 0.001, respectively). It was found that patients with XPD rs13181 Lys/Gln had a significantly higher risk of cannabis dependence than control did (p = 0.00). The subjects carried XPD rs13181 Gln/Gln genotype had a 2.2-fold increased risk for cannabis dependence (p = 0.010). CONCLUSIONS: We demonstrated for the first time that DNA repair gene variants may alter individual vulnerability for SUD. This observation could be of further interest to researchers, as it could suggest new candidate genes, presumably crucial for the etiopathogenesis of the cannabis and/or synthetic cannabis dependence. © 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.citationPehlivan, S., Yazıcı, A. B., Aydın, N., Nursal, A. F., Kurnaz, S., Öngel Atar, A., Sever, Ü., Kıncır, Z. [et. al.]. (2018). Possible association between DNA repair gene variants and cannabis dependence in a Turkish cohort: a pilot study. Psychiatry and Clinical Psychopharmacology, 28(4), 402-407.
dc.identifier.doi10.1080/24750573.2018.1468615
dc.identifier.endpage407en_US
dc.identifier.issn2475-0573
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage402en_US
dc.identifier.urihttps://doi.org/10.1080/24750573.2018.1468615
dc.identifier.urihttps://hdl.handle.net/11491/1914
dc.identifier.volume28en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofPsychiatry and Clinical Psychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectCannabisen_US
dc.subjectDNA Repairen_US
dc.subjectSubstance Use Disorderen_US
dc.subjectXPDen_US
dc.subjectXRCC1en_US
dc.subjectXRCC4en_US
dc.titlePossible association between DNA repair gene variants and cannabis dependence in a Turkish cohort: a pilot study
dc.typeArticle

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