Characterization of p(PmO), p(LO) and p(RO) organoparticles, their bioactivity properties and their effect on pancreatic cancer Capan-1 cell

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dc.contributor.authorAlpaslan, Duygu
dc.contributor.authorTuran, Abdullah
dc.contributor.authorErsen Dudu, Tuba
dc.contributor.authorMoran Bozer, Büşra
dc.contributor.authorAktaş, Nahit
dc.contributor.authorTürk, Mustafa
dc.date.accessioned2024-02-01T07:57:38Z
dc.date.available2024-02-01T07:57:38Z
dc.date.issued2023en_US
dc.departmentRektörlük
dc.description.abstractFor the first time in the literature, p (PmO), p (LO) and p (RO) organo-particles were synthesized from Peppermint oil, Lemon oil and Rose oil. Of the organo-particles L-929 cell line viability/cytotoxicity and anticancer effect against Capan-1 pancreatic cancer cell line were investigated. p (PmO), p (LO) and p (RO) organo-particles were featured by thermogravimetry (TGA), Fourier Transform Infrared Spectroscopy (FTIR), Scanning electron microscope (SEM), Particle size (DLS), and particle charge (zeta potential, Zeta) analyses. Antioxidant, biocompatible, and antimicrobial activities and in vitro cytotoxicity specialties were investigated. In studies on Capan-1 and L-929 cell lines, it was observed that p (PmO), p (LO) and p (RO) organo-particles were effective on L-929 fibroblast cell line on Capan-1 pancreatic cancer cell line. In addition, it was observed that p (PmO), p (LO) and p (RO) organo-particles were not toxic in L-929 cell lines at high doses. When the Capan-1 cell line MTT analysis results of p (PmO), p (LO) and p (RO) organo-particles were examined, a difference was observed between cell viability rates and apoptosis and necrosis values. The highest % apoptosis rate was observed in the p (RO) organo particle.
dc.description.provenanceSubmitted by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-02-01T07:57:27Z No. of bitstreams: 0en
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dc.description.provenanceMade available in DSpace on 2024-02-01T07:57:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2023en
dc.identifier.citationAlpaslan, D., Turan, A., Dudu, T. E., Bozer, B. M., Aktas, N., & Turk, M. (2023). Characterization of p (PmO), p (LO) and p (RO) organoparticles, their bioactivity properties and their effect on pancreatic cancer Capan-1 cell. Materials Chemistry and Physics, 305, 127871.
dc.identifier.doi10.1016/j.matchemphys.2023.127871
dc.identifier.issn0254-0584
dc.identifier.issn1879-3312
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.matchemphys.2023.127871
dc.identifier.urihttps://hdl.handle.net/11491/8777
dc.identifier.wosWOS:001017132100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorMoran Bozer, Büşra
dc.language.isoen
dc.publisherELSEVIER SCIENCE SA
dc.relation.ispartofMaterials Chemistry and Physics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOrgano particleen_US
dc.subjectPeppermint oilen_US
dc.subjectLemon oilen_US
dc.subjectRosa oilen_US
dc.subjectCapan-1en_US
dc.subjectL-929en_US
dc.titleCharacterization of p(PmO), p(LO) and p(RO) organoparticles, their bioactivity properties and their effect on pancreatic cancer Capan-1 cell
dc.typeArticle

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