Changes in the before and after thyroxine treatment levels of adipose tissue, leptin, and resistin in subclinical hypothyroid patients

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dc.contributor.authorAkbaba, Gülhan
dc.contributor.authorBerker, Dilek
dc.contributor.authorIşık, Serhat
dc.contributor.authorTuna, Mazhar Müslüm
dc.contributor.authorKoparal, Suha
dc.contributor.authorVural, Murat
dc.contributor.authorYılmaz, Fatma Meriç
dc.contributor.authorTopçuoğlu, Canan
dc.contributor.authorGüler, Serdar
dc.date.accessioned2019-05-10T09:39:21Z
dc.date.available2019-05-10T09:39:21Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: Subclinical hypothyroidism (SH) occurs when serum thyroid stimulating hormone (TSH) concentrations are raised and serum thyroid hormone concentrations are normal. The effect of SH on the proinflammatory adipose cytokine releasing visceral adipose tissue (VAT) is not clear. The aim of this study is to identify the difference between the pre and posttreatment levels of VAT, leptin, and resistin in SH patients. Methods: There were 51 SH patients and 43 age- and gender-matched healthy subjects included in the study. Thyroid functions, biochemical tests, leptin, resistin, and visceral and subcutaneous fat measurements were made. The measurements were repeated in the SH group in the third month following L-thyroxin treatment. Results: Initially, high sensitivity C-reactive protein, carotid artery intima-media thickness (mm), leptin, and resistin levels were significantly higher in the SH group compared to the controls, while the other parameters were similar. While no correlation was observed between TSH levels and adipokines, a positive correlation was detected between waist circumference and leptin levels (r = 0.549, p < 0.01). Visceral adipose tissue was positively correlated to age, waist circumference, and leptin levels, but negatively correlated to free thyroxin (T4) levels (r = 0.419, p = 0.009; r = 0.794, p < 0.01; r = 0.515, p < 0.01 and r = - 0.416, p = 0.009, respectively). A significant decrease was observed in VAT volume, leptin, and resistin levels of SH patients following levothyroxine treatment. Conclusion The reduced VAT volume, leptin, and resistin levels in SH patients following treatment may support the idea that TSH affects adipose tissue functions. © 2015, Springer-Verlag Wien.
dc.identifier.citationAkbaba, G., Berker, D., Isık, S., Tuna, M. M., Koparal, S., Vural, M., ... & Guler, S. (2016). Changes in the before and after thyroxine treatment levels of adipose tissue, leptin, and resistin in subclinical hypothyroid patients. Wiener Klinische Wochenschrift, 128(15-16), 579-585.
dc.identifier.doi10.1007/s00508-015-0865-9
dc.identifier.endpage585en_US
dc.identifier.issn0043-5325
dc.identifier.issue15-16en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage579en_US
dc.identifier.urihttps://doi.org/10.1007/s00508-015-0865-9
dc.identifier.urihttps://hdl.handle.net/11491/675
dc.identifier.volume128en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer-Verlag Wien
dc.relation.ispartofWiener Klinische Wochenschrift
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLeptinen_US
dc.subjectResistinen_US
dc.subjectSubclinical Hypothyroidismen_US
dc.subjectThyroid Stimulating Hormoneen_US
dc.subjectVisceral Adipose Tissueen_US
dc.titleChanges in the before and after thyroxine treatment levels of adipose tissue, leptin, and resistin in subclinical hypothyroid patients
dc.typeArticle

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