Boric acid: A simple molecule of physiologic, therapeutic and prebiotic significance
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Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Walter de Gruyter GmbH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Boric acid, H3BO3, is a weak acid and at physiological pH is in the form of an uncharged small molecule. Behaving as a Lewis acid, it forms complexes with amino- and hydroxy acids, carbohydrates, nucleotides and vitamins through electron donor-acceptor interactions. These interactions are believed to be beneficial for human health. Synthetic bis-chelate complexes of boric acid with organic biomolecules are therefore considered for nutritional and/or pharmaceutical applications. The use of boric acid for BNCT has gained attention due to the short biological half-life, solubility, plasma circulation and the non-selective soft tissue accumulation properties of this simple molecule. Complexation of boric acid with sugars is of particular importance in understanding the role of boron as a carrier for nucleotides and carbohydrates. A potential and catalytic role of boric acid in peptide and nucleic acid synthesis and in the stabilization of sugar molecules by acting as a complexing agent have been demonstrated. Its possible role as a phosphorylation chaperone in a prebiotic world has been recently suggested. This contribution reviews the highlights in the physiologic, therapeutic and prebiotic significance of boric acid in the last decade. © 2014 IUPAC & De Gruyter.
Açıklama
Anahtar Kelimeler
Borate Complex, Borate Ester, Boric Acid, IMEBORON-XV, Prebiotic Chemistry
Kaynak
Pure and Applied Chemistry
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
87
Sayı
2
Künye
Zumreoglu-Karan, B., & Kose, D. A. (2015). Boric acid: a simple molecule of physiologic, therapeutic and prebiotic significance. Pure and Applied Chemistry, 87(2), 155-162.
