Boric acid: A simple molecule of physiologic, therapeutic and prebiotic significance

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dc.contributor.authorZümreoğlu Karan, Birgül
dc.contributor.authorKöse, Dursun Ali
dc.date.accessioned2019-05-10T09:39:14Z
dc.date.available2019-05-10T09:39:14Z
dc.date.issued2015
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractBoric acid, H3BO3, is a weak acid and at physiological pH is in the form of an uncharged small molecule. Behaving as a Lewis acid, it forms complexes with amino- and hydroxy acids, carbohydrates, nucleotides and vitamins through electron donor-acceptor interactions. These interactions are believed to be beneficial for human health. Synthetic bis-chelate complexes of boric acid with organic biomolecules are therefore considered for nutritional and/or pharmaceutical applications. The use of boric acid for BNCT has gained attention due to the short biological half-life, solubility, plasma circulation and the non-selective soft tissue accumulation properties of this simple molecule. Complexation of boric acid with sugars is of particular importance in understanding the role of boron as a carrier for nucleotides and carbohydrates. A potential and catalytic role of boric acid in peptide and nucleic acid synthesis and in the stabilization of sugar molecules by acting as a complexing agent have been demonstrated. Its possible role as a phosphorylation chaperone in a prebiotic world has been recently suggested. This contribution reviews the highlights in the physiologic, therapeutic and prebiotic significance of boric acid in the last decade. © 2014 IUPAC & De Gruyter.
dc.identifier.citationZumreoglu-Karan, B., & Kose, D. A. (2015). Boric acid: a simple molecule of physiologic, therapeutic and prebiotic significance. Pure and Applied Chemistry, 87(2), 155-162.
dc.identifier.doi10.1515/pac-2014-0909
dc.identifier.endpage162en_US
dc.identifier.issn0033-4545
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.1515/pac-2014-0909
dc.identifier.urihttps://hdl.handle.net/11491/641
dc.identifier.volume87en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWalter de Gruyter GmbH
dc.relation.ispartofPure and Applied Chemistry
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBorate Complexen_US
dc.subjectBorate Esteren_US
dc.subjectBoric Aciden_US
dc.subjectIMEBORON-XVen_US
dc.subjectPrebiotic Chemistryen_US
dc.titleBoric acid: A simple molecule of physiologic, therapeutic and prebiotic significance
dc.typeConference Object

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