The effect of probiotics on intestinal motility in an experimental short bowel model

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dc.authoridAltun, Ahmet / 0000-0003-2056-8683
dc.authoridKoyluoglu, Gokhan / 0000-0002-1140-169X
dc.contributor.authorMetin, Mehmet
dc.contributor.authorAltun, Ahmet
dc.contributor.authorKoyluoglu, Gokhan
dc.date.accessioned2021-11-01T15:03:14Z
dc.date.available2021-11-01T15:03:14Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractPurpose: To investigate the effect of probiotics on spontaneous contractions of smooth muscle isolated from jejunum and ileum of rat model. Methods: Four rat groups were created (n=8, in each) including control (Group 1), control+probiotic (Group 2), short bowel (Group 3), and short bowel+probiotic (Group 4). Groups 1 and 2 underwent sham operation, Groups 3 and 4 underwent massive bowel resection. Bifidobacterium Lactis was administered in Groups 2 and 4 daily (P.O.) for three weeks. On postoperative week 3, rats were sacrificed, and jejunum and ileum smooth muscle were isolated for organ bath. Muscle contraction changes were analyzed before and after addition of antagonists. Results: Short bowel group exhibited increased amplitude and frequency of spontaneous contractions. The addition of probiotics significantly decreased enhanced amplitude and frequency of bowel contraction in short bowel group and returned to control values. L-NNA increased amplitude and frequency of contractions in all groups. While indomethacin and nimesulide increased the amplitude in all groups, the frequency was only increased in jejunum. Hexamethonium and tetrodotoxin did not change the contraction characteristics in all groups. Conclusion: We suggest that early use of probiotics may significantly regulate bowel motility, and accordingly improve absorption of nutrients in short bowel syndrome.
dc.identifier.doi10.1590/s0102-865020200080000004
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue8en_US
dc.identifier.pmid32901681
dc.identifier.scopus2-s2.0-85090665601
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/s0102-865020200080000004
dc.identifier.urihttps://hdl.handle.net/11491/7033
dc.identifier.volume35en_US
dc.identifier.wosWOS:000566687400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectShort Bowel Syndromeen_US
dc.subjectGastrointestinal Motilityen_US
dc.subjectProbioticsen_US
dc.subjectAmplitudeen_US
dc.subjectRatsen_US
dc.titleThe effect of probiotics on intestinal motility in an experimental short bowel model
dc.typeArticle

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