The role of adhesion molecules and cytokines in patients with diabetic nephropathy

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dc.authorid0000-0003-1046-8208
dc.contributor.authorAvcı, Emre
dc.contributor.authorUzeli, Sevil
dc.date.accessioned2019-05-13T09:08:18Z
dc.date.available2019-05-13T09:08:18Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractDiabetic Nephropathy (DN) is one of the major microvascular complications of diabetes mellitus. There are immune disorders observed in these patients realized with the changes on the cell adhesion molecules and the cytokine levels because of various reasons. Therefore, the simultaneous determination and evaluation of adhesion molecules (sVCAM-1, sICAM, sPCAM-I, E-selectin and P-selectin) and the levels of cytokines (IL-2 and TGF-B) in patients with DN undergoing dialysis therapy for chronic renal failure was aimed in this study. The levels of all parameters were determined by immune-enzyme assay method. Notwithstanding that the values of the parameters of sVCAM, sICAM, pCAM-I, E-selectin and P-selectin were significantly higher before and after dialysis as compared to those of control group. The values of IL-2 and TGF beta-I were found to be increased as compared to those of the control group. After the comparison of the IL-2 values obtained before and after-dialysis, the values obtained afterdialysis were determined higher as compared to those of the control group and the values obtained before-dialysis. It was determined that TGF beta-I values obtained after dialysis are decrease in the values obtained before-dialysis. In our study, it was determined that there is an increase in all values obtained after-dialysis as compared to those obtained before-dialysis. Our study reveals the relation between the dialysis and the increase obtained the parameters studied. Changes occurring in adhesion and cytokine levels of patients with diabetic nephropathy are important in terms predetermination of potential complications and role of dialysis treatment. © 2016, Scientific Publishers of India. All rights reserved.
dc.identifier.citationAvcı, E., Uzeli, S. (2016). The role of adhesion molecules and cytokines in patients with diabetic nephropathy.Biomedical Research (India), 2016(1), S343-S348.
dc.identifier.endpageS348en_US
dc.identifier.issn0970-938X
dc.identifier.issueSpecial Issue 1en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpageS343en_US
dc.identifier.urihttps://hdl.handle.net/11491/1972
dc.identifier.volume2016en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherScientific Publishers of India
dc.relation.ispartofBiomedical Research (India)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCell Adhesion Moleculesen_US
dc.subjectChronic Renal Failureen_US
dc.subjectCytokinesen_US
dc.subjectDiabetic Nephropathyen_US
dc.subjectHaemodialysisen_US
dc.titleThe role of adhesion molecules and cytokines in patients with diabetic nephropathy
dc.typeArticle

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