Diagnosis, treatment & management of prosthetic valve thrombosis: the key considerations

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dc.authoridGündüz, Sabahattin / 0000-0003-0704-5335
dc.authoridKalçık, Macit / 0000-0002-8791-4475
dc.contributor.authorGündüz, Sabahattin
dc.contributor.authorKalçık, Macit
dc.contributor.authorGürsoy, Mustafa Ozan
dc.contributor.authorGüner, Ahmet
dc.contributor.authorÖzkan, Mehmet
dc.date.accessioned2021-11-01T15:05:18Z
dc.date.available2021-11-01T15:05:18Z
dc.date.issued2020
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractIntroduction: Prosthetic heart valve thrombosis is a life-threatening complication after valve replacement surgery. Although subtherapeutic anticoagulation is the main cause, there are many other conventional and esoteric predisposing factors. Areas covered: The etiopathogenesis, diagnosis, and management of prosthetic heart valve thrombosis with particular focus on conventional and esoteric predisposing factors, diagnosis with multimodality imaging and current therapeutic approaches were covered. Expert opinion: Subtherapeutic anticoagulation remains the key driving force for the development of prosthetic valve thrombosis. However, cardiologists should be cognizant of other frequent or rare conventional and esoteric causes. The diagnosis is now more straightforward with the use of multimodality imaging. Transthoracic and transesophageal echocardiography with or without real-time three-dimensional imaging are the current gold standard modalities. Multidetector computed tomography is now a major complementary tool. The favorable clinical outcomes with recently introduced slow or ultra-slow infusions of alteplase, as compared to relatively poor surgical results, have rendered thrombolytic therapy the first-line treatment option in most eligible patients with prosthetic valve thrombosis. Surgical treatment could be reserved in whom thrombolytic therapy is contraindicated or has already failed. The efficacy and safety of thrombolytic therapy as compared to surgery should be confirmed with large observational cohorts, and ideally randomized trials.
dc.identifier.citationGündüz, S., Kalçık, M., Gürsoy, M. O., Güner, A., & Özkan, M. (2020). Diagnosis, treatment & management of prosthetic valve thrombosis: the key considerations. Expert review of medical devices, 17(3), 209-221.
dc.identifier.doi10.1080/17434440.2020.1733972
dc.identifier.endpage221en_US
dc.identifier.issn1743-4440
dc.identifier.issn1745-2422
dc.identifier.issue3en_US
dc.identifier.pmid32085683
dc.identifier.scopus2-s2.0-85081244672
dc.identifier.scopusqualityQ1
dc.identifier.startpage209en_US
dc.identifier.urihttps://doi.org/10.1080/17434440.2020.1733972
dc.identifier.urihttps://hdl.handle.net/11491/7218
dc.identifier.volume17en_US
dc.identifier.wosWOS:000518236300008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKalçık, Macit
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofExpert Review Of Medical Devices
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectValveen_US
dc.subjectProsthesisen_US
dc.subjectEchocardiographyen_US
dc.subjectThrombolysisen_US
dc.subjectPannusen_US
dc.titleDiagnosis, treatment & management of prosthetic valve thrombosis: the key considerations
dc.typeReview Article

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