Investigation of Effects of Two Chronic Stress Protocols on Depression-Like Behaviors and Brain Mineral Levels in Female Rats: an Evaluation of 7-Day Immobilization Stress

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dc.authoridSahin, Zafer / 0000-0001-7982-7155
dc.authoridKutlu, Selim / 0000-0001-9257-4797
dc.authoridKALKAN, Omer Faruk / 0000-0002-7574-1183
dc.authorwosidSolak, Hatice / AAN-3214-2021
dc.authorwosidSahin, Zafer / ABD-5367-2020
dc.authorwosidKutlu, Selim / AAQ-5501-2021
dc.authorwosidKALKAN, Omer Faruk / AAR-2157-2020
dc.contributor.authorSahin, Z.
dc.contributor.authorOzkurkculer, A.
dc.contributor.authorKalkan, O. F.
dc.contributor.authorOzkaya, A.
dc.contributor.authorKoç, Aynur
dc.contributor.authorKoca, R. Ozen
dc.contributor.authorKutlu, S.
dc.date.accessioned2021-11-01T15:05:59Z
dc.date.available2021-11-01T15:05:59Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractWe aimed to investigate the effects of two different chronic immobilization stress protocols on depression-related behaviors and brain mineral levels. Adult female Wistar albino rats were divided into 3 groups as follows (n = 10/group): control, immobilization stress-1 (45 min daily for 7 days), and immobilization stress-2 (45 min twice a day for 7 day). Stress-related behavior was evaluated by means of the forced swimming test (FST) and open field test (OFT). Minerals were analyzed using an inductively coupled plasma mass spectrometer. In the FST, swimming and immobility were significantly lower in the immobilization stress-1 and immobilization stress-2 groups. The climbing duration of the immobilization stress-2 group was higher than the control group. In the OFT, percentage of time spent in the central area was significantly lower in the immobilization stress-1 and immobilization stress-2 groups. Values of latency to center area, rearing, and grooming did not significantly differ between groups. In the immobilization stress-1 group, zinc was lower, and iron, copper, and manganese were higher than the control group. In the immobilization stress-2 group, copper and manganese were higher, and phosphate was lower than the control group. Our results showed that depression-related behaviors were more dominant in the immobilization stress-1 group. A decrease in the brain zinc level was valid only for the immobilization stress-1 group. These results point to the role of low brain zinc levels in the pathophysiology of depression.
dc.identifier.doi10.1007/s12011-020-02160-5
dc.identifier.endpage667en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid32328969
dc.identifier.scopus2-s2.0-85084118747
dc.identifier.scopusqualityQ1
dc.identifier.startpage660en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-020-02160-5
dc.identifier.urihttps://hdl.handle.net/11491/7458
dc.identifier.volume199en_US
dc.identifier.wosWOS:000528515500002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectImmobilizationen_US
dc.subjectBrainen_US
dc.subjectDepressionen_US
dc.subjectAnxietyen_US
dc.subjectZincen_US
dc.subjectCopperen_US
dc.subjectManganeseen_US
dc.subjectRaten_US
dc.titleInvestigation of Effects of Two Chronic Stress Protocols on Depression-Like Behaviors and Brain Mineral Levels in Female Rats: an Evaluation of 7-Day Immobilization Stress
dc.typeArticle

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