Low level of Nesfatin-1 is associated with gestational diabetes mellitus

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dc.authorid0000-0002-0848-9731
dc.contributor.authorKüçükler, Ferit Kerim
dc.contributor.authorGörkem, Ümit
dc.contributor.authorŞimşek, Yasin
dc.contributor.authorKocabaş, Ramazan
dc.contributor.authorGülen, Şebnem
dc.contributor.authorGüler, Serdar
dc.date.accessioned2019-05-13T08:58:18Z
dc.date.available2019-05-13T08:58:18Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractIntroduction: Gestational diabetes mellitus (GDM) occurs in similar to 10-25% of pregnancies. Nesfatin-1, plays a role in carbohydrate metabolism by inhibiting glucagon secretion, besides has a glucose-dependent insulinotropic effect. Explanation of the GDM pathogenesis is important due to preventing gestational complications. We aimed to investigate relationship between GDM and Nesfatin-1. Material and methods: Seventy-nine pregnant subjects were randomly allocated to either GDM group (GDG, n = 38) or control group (CG, n = 41). For GDM diagnosis, 50 and 100 g oral glucose tolerance test (OGTT) were used. Nesfatin-1, insulin and other parameters were measured for all subjects. The homeostasis model assessment-insulin resistance (HOMA-IR) was calculated.Results: Nesfatin-1 was found lower and insulin was found higher in GDG than CG. Negative correlation has been founded between Nesfatin-1 with weight, BMI, fasting glucose, serum glucose level at first hour of the 50 g OGTT and HOMA-IR.Conclusion: In this study, patients with GDM had lower Nesfatin-1 levels than without GDM. Therefore, when the Nesfatin-1 effects on the GDM pathogenesis is clear, it may be contributed to diagnosis and treatment of the GDM.
dc.identifier.citationKucukler, F. K., Gorkem, U., Simsek, Y., Kocabas, R., Gulen, S., & Guler, S. (2016). Low level of Nesfatin-1 is associated with gestational diabetes mellitus. Gynecological Endocrinology, 32(9), 759-761.
dc.identifier.doi10.1080/09513590.2016.1180679
dc.identifier.endpage761en_US
dc.identifier.issn0951-3590
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage759en_US
dc.identifier.urihttps://doi.org/10.1080/09513590.2016.1180679
dc.identifier.urihttps://hdl.handle.net/11491/1109
dc.identifier.volume32en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGestational Diabetes Mellitusen_US
dc.subjectInsulin Resistanceen_US
dc.subjectNesfatin-1en_US
dc.titleLow level of Nesfatin-1 is associated with gestational diabetes mellitus
dc.typeArticle

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