Highly sensitive carbon-based nanohybrid sensor platform for determination of 5-hydroxytryptamine receptor agonist (Eletriptan)

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dc.authoridKurbanoglu, Sevinc / 0000-0002-7079-7604
dc.authoridKaya, S. Irem / 0000-0003-0578-5399
dc.authoridSEN, FATIH / 0000-0001-9929-9556
dc.authorwosidKurbanoglu, Sevinc / AAG-5743-2021
dc.authorwosidKaya, S. Irem / AAA-3568-2021
dc.contributor.authorKaya, S. I.
dc.contributor.authorDemirkan, B.
dc.contributor.authorBakirhan, N. K.
dc.contributor.authorKuyuldar, E.
dc.contributor.authorKurbanoglu, S.
dc.contributor.authorOzkan, S. A.
dc.contributor.authorSen, F.
dc.date.accessioned2021-11-01T15:02:55Z
dc.date.available2021-11-01T15:02:55Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractHighly sensitive nanosensors such as graphene oxide/ platinum-iridium nanohybrid, carboxylic acid functionalized multiwalled carbon nanotubes (GO/Pt-Ir/MWCNT-COOH) and amine functionalized multiwalled carbon nanotubes (GO/Pt-Ir/MWCNT-NH2) modified glassy carbon electrode were developed for the determination of 5-hydroxytryptamine receptor agonist, Eletriptan. Graphene oxide/platinum-iridium nanohybrid was synthesized using sonication method and then characterized by spectroscopic and microscopic methods such as Raman, TEM, HRTEM, XPS, and XRD. The prepared nanohybrids modified on glassy carbon electrodes were well characterized and applied for electrochemical determination of Eletriptan. The significant enhancement of the oxidation peak current of Eletriptan was observed in GO/Pt-Ir/MWCNT-COOH as a best nanosensor in all prepared ones. The pH, scan rate and the amount of GO/Pt-Ir/MWCNT-COOH were also optimized for Eletriptan analysis. After obtaining of the optimum conditions, the identification of Eletriptan was performed between the linear range of 1 x 10(-7) M and 4 x 10(-6) M with a detection limit of 6.1 x 10(-9) M. The developed method was successfully applied for the determination of the drug in tablets with acceptable recoveries. Moreover, it can be elicited that, in electrochemical studies, electroactive interferences from the tablet excipients did not interfere with the results. (C) 2019 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.jpba.2019.05.070
dc.identifier.endpage213en_US
dc.identifier.issn0731-7085
dc.identifier.issn1873-264X
dc.identifier.pmid31176930
dc.identifier.scopus2-s2.0-85066622347
dc.identifier.scopusqualityQ1
dc.identifier.startpage206en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpba.2019.05.070
dc.identifier.urihttps://hdl.handle.net/11491/6859
dc.identifier.volume174en_US
dc.identifier.wosWOS:000479328000024
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal Of Pharmaceutical And Biomedical Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEletriptanen_US
dc.subjectDrug analysesen_US
dc.subjectGraphene oxideen_US
dc.subjectPlatinum-iridium nanohybriden_US
dc.subjectMultiwalled carbon nanotubesen_US
dc.subjectVoltammetryen_US
dc.titleHighly sensitive carbon-based nanohybrid sensor platform for determination of 5-hydroxytryptamine receptor agonist (Eletriptan)
dc.typeArticle

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