Influence of ESR1 Variants on Clinical Characteristics and Fibromyalgia Syndrome in Turkish Women

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dc.authoridNursal, Ayse Feyda / 0000-0001-7639-1122
dc.contributor.authorArslan, Habibe S.
dc.contributor.authorNursal, Ayse F.
dc.contributor.authorInanir, Ahmet
dc.contributor.authorKarakus, Nevin
dc.contributor.authorYigit, Serbulent
dc.date.accessioned2021-11-01T15:06:05Z
dc.date.available2021-11-01T15:06:05Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractBackground: Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal pain. It is more common in women than in men, and sex hormones may play a role in this predominance. Therefore, this research investigated the clinical findings among Turkish females and whether Estrogen-alpha (ESR1) gene variants are associated with FMS. Methods: A total of 219 individuals were enrolled in this study. ESR1 variants (Pvull/XbaI) were genotyped using PCR-RFLP methods. The results of the analyses were evaluated for statistical significance. Results: There was a significant association between the ESR1 PvuII and FMS risk among Turkish women. The ESR1 PvuII CC genotype and C allele were higher in the patients than those in the controls (p=0.021, p=0.007, respectively). A more statistically significant association was observed between the patients and the controls in terms of TT genotype vs. TC+CC genotypes (p=0.022). Also, there was a statistically significant association between the patients and the controls in terms of TT+TC genotype vs. CC genotypes (p =0.028). There was no significant association between patients and the control group concerning the genotype distribution and allele frequencies of ESR1 XbaI (p>0.05). Headache was seen more frequently in the XbaI GA genotype (p =0.025), while XbaI AA genotype was associated with dysmenorrhea in patients with FMS (p=0.041). Conclusion: Our results indicate that ESR1 PvuII/XbaI variants are possibly effective in the development of FMS and some clinical features.
dc.identifier.doi10.2174/1871530320666200910110915
dc.identifier.endpage1332en_US
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.issue7en_US
dc.identifier.pmid32914729
dc.identifier.scopus2-s2.0-85113464976
dc.identifier.scopusqualityQ2
dc.identifier.startpage1326en_US
dc.identifier.urihttps://doi.org/10.2174/1871530320666200910110915
dc.identifier.urihttps://hdl.handle.net/11491/7488
dc.identifier.volume21en_US
dc.identifier.wosWOS:000687972400003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofEndocrine Metabolic & Immune Disorders-Drug Targets
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFibromiyalgia syndromeen_US
dc.subjectestrogen receptor-alphaen_US
dc.subjectPvullen_US
dc.subjectXbaIen_US
dc.subjectvarianten_US
dc.subjectwomenen_US
dc.titleInfluence of ESR1 Variants on Clinical Characteristics and Fibromyalgia Syndrome in Turkish Women
dc.typeArticle

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