The Comparison Spondin 2 Levels in Primary Glomerular Diseases

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dc.authoridErsoy, Alparslan / 0000-0002-0710-0923
dc.authorwosidErsoy, Alparslan / AAH-5054-2021
dc.authorwosidAyar, Yavuz / O-9948-2015
dc.authorwosidOruc, Aysegul / AAH-4002-2021
dc.contributor.authorKahvecioglu, Serdar
dc.contributor.authorErsoy, Alparslan
dc.contributor.authorUEstundag, Yasemin
dc.contributor.authorAyar, Yavuz
dc.contributor.authorGul, Cuma Bulent
dc.contributor.authorYildiz, Abduelmecit
dc.contributor.authorOruc, Aysegul
dc.date.accessioned2021-11-01T15:05:14Z
dc.date.available2021-11-01T15:05:14Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractSpondin 2 (SPON2) plays an important role in multiple processes and is a member of the Spondin 2/F-spondin family of extracellular matrix proteins. We investigated serum SPON2 levels and its correlation with renal functions and urine protein excretion in different glomerular diseases. The cohort included 97 consecutive adults with persistant proteinuria (>300 mg/day) with the diagnosis of focal segmental glomerulosclerosis (FSGS), membranous glomerulonephritis (MN), IgA nephropathy (IgAN), membranoproliferative glomerulonephritis (MPGN), and AA amyloidosis and the control groups with 15 polycystic kidney disease (PKD) and 32 healthy people. Serum SPON2 levels in MN (64.6 ng/mL), FSGS (47.8 ng/mL), IgAN (52.6 ng/mL), MPGN (54.6 ng/mL), and AA amyloidosis (60.7 ng/mL) groups were higher than those of the control (26.4 ng/mL) and nonglomerular disease groups (PKD) (15.3 ng/mL). Only serum SPON2 levels were correlated with serum uric acid and triglyceride levels in patients with glomerular disease. This is the first study to show that serum SPON2 levels are similar in different glomerular diseases and that there is no correlation between SPON2 and proteinuria grade.
dc.identifier.doi10.4103/1319-2442.301166
dc.identifier.endpage1024en_US
dc.identifier.issn1319-2442
dc.identifier.issn2320-3838
dc.identifier.issue5en_US
dc.identifier.pmid33229764
dc.identifier.scopus2-s2.0-85096728103
dc.identifier.scopusqualityQ3
dc.identifier.startpage1014en_US
dc.identifier.urihttps://doi.org/10.4103/1319-2442.301166
dc.identifier.urihttps://hdl.handle.net/11491/7186
dc.identifier.volume31en_US
dc.identifier.wosWOS:000596487500004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofSaudi Journal Of Kidney Diseases And Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject[No Keywords]en_US
dc.titleThe Comparison Spondin 2 Levels in Primary Glomerular Diseases
dc.typeArticle

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