Vitamin D Levels in Patients with Recurrent Herpes Labialis

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dc.authorwosidErtan, Asli / AAE-6201-2021
dc.contributor.authorOztekin, Aynure
dc.contributor.authorOztekin, Coskun
dc.date.accessioned2021-11-01T15:01:56Z
dc.date.available2021-11-01T15:01:56Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractRecurrent infections of herpes simplex virus in the orolabial area are known as recurrent herpes labialis (RHL). Vitamin D has been shown to have an important immunomodulatory role and to be associated with several infectious diseases. This hospital-based case-control study aimed at investigating the association between vitamin D and RHL by comparing vitamin D levels in individuals with and without RHL. Individuals who presented to the dermatology clinic at a state hospital due to RHL (n = 50) and matching control group of healthy volunteers (n = 51) were studied. Their vitamin D levels were measured, stratified based on clinical guidelines, and compared. The average serum vitamin D (25-hydroxyvitamin D) levels were 23.8 +/- 15.5 and 42.0 +/- 26.3 nM in the patient and control groups, with significant differences between their average serum vitamin D levels and vitamin D status. The studied population had serious vitamin D deficiency regardless of having RHL, with vitamin D levels below the adequate limits in more than 96% of the population. Most importantly, the study established a significant association between low serum vitamin D levels and the presence of RHL. Further interventional and pathophysiological studies should clarify the nature and mechanism of the relationship.
dc.identifier.doi10.1089/vim.2019.0013
dc.identifier.endpage262en_US
dc.identifier.issn0882-8245
dc.identifier.issn1557-8976
dc.identifier.issue6en_US
dc.identifier.pmid31145049
dc.identifier.scopus2-s2.0-85069210098
dc.identifier.scopusqualityQ3
dc.identifier.startpage258en_US
dc.identifier.urihttps://doi.org/10.1089/vim.2019.0013
dc.identifier.urihttps://hdl.handle.net/11491/6772
dc.identifier.volume32en_US
dc.identifier.wosWOS:000469515400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofViral Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectvitamin Den_US
dc.subjectimmune systemen_US
dc.subjectherpes simplex virusen_US
dc.subjectrecurrent herpes labialisen_US
dc.titleVitamin D Levels in Patients with Recurrent Herpes Labialis
dc.typeArticle

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