Zinc and Magnesium Levels of Pregnant Women with Restless Leg Syndrome and Their Relationship with Anxiety: A Case-Control Study

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dc.authoridApaydin, Hakan / 0000-0001-8507-6212
dc.authorwosidYildirim, Engin / AAZ-2330-2021
dc.contributor.authorYildirim, Engin
dc.contributor.authorApaydin, Hakan
dc.date.accessioned2021-11-01T15:05:27Z
dc.date.available2021-11-01T15:05:27Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractRestless leg syndrome (RLS) is a multifactorial movement disorder, and pregnancy is seen as a risk factor. This study aims to determine the clinical and psychiatric causes of RLS with a case-control study. The hemogram, biochemistry data, thyroid function tests, and serum element levels of healthy pregnant women (n = 134) and pregnant women diagnosed with RLS (n = 119) were compared. Total Ca, Mg, K, and Na concentrations were measured with an inductively coupled plasma optical emission spectrometry (ICP-OES), and an atomic absorption spectrophotometer was used to measure total concentrations of Zn in all samples. The Beck Anxiety Inventory (BAI), the Beck Depression Inventory (BDI), and the Pittsburg Sleep Quality Index (PSQI) scores were also compared in both groups. Sonographic measurements showed that the fetal biparietal diameter and femur lengths were higher in the RLS group (p = 0.001,p = 0.048, respectively), and abortion history was higher in the RLS group (p = 0.016). Magnesium and zinc levels were lower (p < 0.001 for both) and BAI and PSQI scores were higher (p < 0.001 for both) in the RLS group, and there was no difference between the BDI (p = 0.269) scores. A statistically significant relationship was detected between the BAI and RLS scores in the control and RLS groups (p < 0.001 for both). This is the first study to show that magnesium and zinc deficiency may play a role in the etiology of RLS during pregnancy; the results also showed adverse perinatal outcomes such as high miscarriage.
dc.identifier.doi10.1007/s12011-020-02287-5
dc.identifier.endpage1685en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue5en_US
dc.identifier.pmid32676936
dc.identifier.scopus2-s2.0-85088104032
dc.identifier.scopusqualityQ1
dc.identifier.startpage1674en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-020-02287-5
dc.identifier.urihttps://hdl.handle.net/11491/7282
dc.identifier.volume199en_US
dc.identifier.wosWOS:000555587300005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPregnancyen_US
dc.subjectRestless leg syndromeen_US
dc.subjectZincen_US
dc.subjectMagnesiumen_US
dc.subjectAnxietyen_US
dc.titleZinc and Magnesium Levels of Pregnant Women with Restless Leg Syndrome and Their Relationship with Anxiety: A Case-Control Study
dc.typeArticle

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