Is There a Need to Alter the Timing of Anti-Mullerian Hormone Measurement During the Menstrual Cycle?

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dc.contributor.authorGörkem, Ümit
dc.contributor.authorToğrul, Cihan
dc.date.accessioned2021-11-01T15:01:54Z
dc.date.available2021-11-01T15:01:54Z
dc.date.issued2019
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractIntroduction There are numerous conflicting studies which have addressed the question whether the measurement of anti-Mullerian hormone (AMH) concentrations should be done at a certain time during the menstrual cycle. We aimed to investigate AMH fluctuations during the follicular and luteal phases of the menstrual cycle and to determine whether AMH variations, if present, might influence the clinical utility of ovarian reserve markers. Materials and Methods A total of 257 infertile women eligible for inclusion were categorized into three groups based on their total antral follicle count: 1. hypo-response group (< 7 follicles, n = 66), 2. normo-response group (7-19 follicles, n = 98), and 3. hyper-response group (> 19 follicles, n = 93). Results Mean follicular AMH levels were elevated compared to levels in the luteal phase in all response groups (p < 0.001). There were significant and strong positive correlations between follicular and luteal AMH levels in all response groups (Spearman ' s r = 0.822, r = 0.836, and r = 0.899, respectively; p < 0.001 for all groups). Fisher ' s Z-test comparisons of these correlations in all response groups demonstrated that there was no statistically significant difference (Z = 0.277, Z = -1.001, and Z = -1.425, respectively; p < 0.001). Conclusion We found that serum AMH levels in the follicular phase were higher than those in the luteal phase in all three response groups. In current practice, fluctuations in serum AMH concentrations are not large enough to alter the timing of AMH measurements during the menstrual cycle. The issue is important for the assessment of ovarian reserve in infertile women with AMH levels near to the cut-off value.
dc.identifier.citationGorkem, U., & Togrul, C. (2019). Is there a need to alter the timing of anti-müllerian hormone measurement during the menstrual cycle?. Geburtshilfe und Frauenheilkunde, 79(07), 731-737.
dc.identifier.doi10.1055/a-0840-3817
dc.identifier.endpage737en_US
dc.identifier.issn0016-5751
dc.identifier.issn1438-8804
dc.identifier.issue7en_US
dc.identifier.pmid31303661
dc.identifier.scopus2-s2.0-85068901411
dc.identifier.scopusqualityQ2
dc.identifier.startpage731en_US
dc.identifier.urihttps://doi.org/10.1055/a-0840-3817
dc.identifier.urihttps://hdl.handle.net/11491/6745
dc.identifier.volume79en_US
dc.identifier.wosWOS:000477655400016
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGörkem, Ümit
dc.institutionauthorToğrul, Cihan
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofGeburtshilfe Und Frauenheilkunde
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnti-Mullerian Hormoneen_US
dc.subjectAMHen_US
dc.subjectFluctuationen_US
dc.subjectOvarian Reserveen_US
dc.subjectVariationen_US
dc.subjectMeasurementen_US
dc.titleIs There a Need to Alter the Timing of Anti-Mullerian Hormone Measurement During the Menstrual Cycle?
dc.typeArticle

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