Simultaneous determination of amlodipine besylate and rosuvastatin calcium in binary mixtures by voltammetric and chromatographic techniques
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Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Institute for Ionics
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Voltammetric and liquid chromatographic (LC) methods have been developed for the simultaneous determination of amlodipine besylate (AML) and rosuvastatin calcium (ROS) for the first time. Detailed electrochemical behavior and simultaneous voltammetric determination of AML and ROS were investigated in detail using glassy carbon electrode (GCE). High-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography (UPLC) were also developed for the comparison. Voltammetric method exhibited linear dynamic responses for the simultaneous assay of AML and ROS in the concentration range between 0.006 and 2.85 ?g/mL and between 0.01 and 5.00 ?g/mL, with detection limits of 0.001 and 0.003 ?g/mL, respectively. On the other hand, LC methods presented a wider linearity range than that of the SWV method between 0.5 and 100 ?g/mL with the detection limits of 0.011 and 0.027 ?g/mL for AML and 0.034 and 0.042 ?g/mL for ROS by UPLC and HPLC techniques, respectively.
Açıklama
Anahtar Kelimeler
Amlodipine Besylate, Determination, HPLC, Pharmaceuticals, Rosuvastatin Calcium, UPLC, Voltammetry
Kaynak
Ionics
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
22
Sayı
2
Künye
Karadaş Bakırhan, N., Gümüştaş, M., Uslu, B., Özkan, S. A. (2016). Simultaneous determination of amlodipine besylate and rosuvastatin calcium in binary mixtures by voltammetric and chromatographic techniques. Ionics, 22(2), 277-288.
