Simultaneous determination of amlodipine besylate and rosuvastatin calcium in binary mixtures by voltammetric and chromatographic techniques

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dc.contributor.authorKaradaş Bakırhan, Nurgül
dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorUslu, Bengi
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-13T08:58:15Z
dc.date.available2019-05-13T08:58:15Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractVoltammetric and liquid chromatographic (LC) methods have been developed for the simultaneous determination of amlodipine besylate (AML) and rosuvastatin calcium (ROS) for the first time. Detailed electrochemical behavior and simultaneous voltammetric determination of AML and ROS were investigated in detail using glassy carbon electrode (GCE). High-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography (UPLC) were also developed for the comparison. Voltammetric method exhibited linear dynamic responses for the simultaneous assay of AML and ROS in the concentration range between 0.006 and 2.85 ?g/mL and between 0.01 and 5.00 ?g/mL, with detection limits of 0.001 and 0.003 ?g/mL, respectively. On the other hand, LC methods presented a wider linearity range than that of the SWV method between 0.5 and 100 ?g/mL with the detection limits of 0.011 and 0.027 ?g/mL for AML and 0.034 and 0.042 ?g/mL for ROS by UPLC and HPLC techniques, respectively.
dc.identifier.citationKaradaş Bakırhan, N., Gümüştaş, M., Uslu, B., Özkan, S. A. (2016). Simultaneous determination of amlodipine besylate and rosuvastatin calcium in binary mixtures by voltammetric and chromatographic techniques. Ionics, 22(2), 277-288.
dc.identifier.doi10.1007/s11581-015-1534-8
dc.identifier.endpage288en_US
dc.identifier.issn0947-7047
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage277en_US
dc.identifier.urihttps://doi.org/10.1007/s11581-015-1534-8
dc.identifier.urihttps://hdl.handle.net/11491/1100
dc.identifier.volume22en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInstitute for Ionics
dc.relation.ispartofIonics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmlodipine Besylateen_US
dc.subjectDeterminationen_US
dc.subjectHPLCen_US
dc.subjectPharmaceuticalsen_US
dc.subjectRosuvastatin Calciumen_US
dc.subjectUPLCen_US
dc.subjectVoltammetryen_US
dc.titleSimultaneous determination of amlodipine besylate and rosuvastatin calcium in binary mixtures by voltammetric and chromatographic techniques
dc.typeArticle

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