The influence of freeze-thawing conditions on swelling and long-term stability properties of poly(vinyl alcohol) hydrogels for controlled drug release
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Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The preparation of poly(vinyl alcohol) (PVA) hydrogels was succeeded via the freeze-thawing (F/T) method by varying the synthesis parameter conditions. The swelling capacity and long-term stability of the hydrogels were determined as a function of time at pH 2.1, 5.5 and 7.4 and found to be mainly affected by the synthesis parameter conditions. These studies showed that the swelling ratio generally increased with a low number of F/T cycles (2 and 3), high freezing temperature (- 5 and - 16 degrees C) and freeze-dried of drying type for all three pH mediums. The dried hydrogels at room temperature were found to be more stable hydrogels. In addition, the drug release studies of salicylic acid as a drug model were investigated at pH 7.4 and displayed controlled release for 120 h. The release kinetic studies obtained from drug release data demonstrated that the PVA hydrogel fits well into the Higuchi model. The release mechanism of PVA hydrogel was also determined as super case II type.
Açıklama
Anahtar Kelimeler
Poly(vinyl alcohol), Freeze-thawing, Long-term Stability, Salicylic Acid, Drug Release
Kaynak
Polymer Bulletin
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
78
Sayı
12
Künye
Boran, F. (2021). The influence of freeze-thawing conditions on swelling and long-term stability properties of poly (vinyl alcohol) hydrogels for controlled drug release. Polymer Bulletin, 78(12), 7369-7387.
