The influence of freeze-thawing conditions on swelling and long-term stability properties of poly(vinyl alcohol) hydrogels for controlled drug release

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dc.authoridBoran, Filiz / 0000-0002-4315-9949
dc.contributor.authorBoran, Filiz
dc.date.accessioned2021-11-01T15:05:22Z
dc.date.available2021-11-01T15:05:22Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü
dc.description.abstractThe preparation of poly(vinyl alcohol) (PVA) hydrogels was succeeded via the freeze-thawing (F/T) method by varying the synthesis parameter conditions. The swelling capacity and long-term stability of the hydrogels were determined as a function of time at pH 2.1, 5.5 and 7.4 and found to be mainly affected by the synthesis parameter conditions. These studies showed that the swelling ratio generally increased with a low number of F/T cycles (2 and 3), high freezing temperature (- 5 and - 16 degrees C) and freeze-dried of drying type for all three pH mediums. The dried hydrogels at room temperature were found to be more stable hydrogels. In addition, the drug release studies of salicylic acid as a drug model were investigated at pH 7.4 and displayed controlled release for 120 h. The release kinetic studies obtained from drug release data demonstrated that the PVA hydrogel fits well into the Higuchi model. The release mechanism of PVA hydrogel was also determined as super case II type.
dc.identifier.citationBoran, F. (2021). The influence of freeze-thawing conditions on swelling and long-term stability properties of poly (vinyl alcohol) hydrogels for controlled drug release. Polymer Bulletin, 78(12), 7369-7387.
dc.identifier.doi10.1007/s00289-021-03902-8
dc.identifier.endpage7387en_US
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85116300994
dc.identifier.scopusqualityQ1
dc.identifier.startpage7369en_US
dc.identifier.urihttps://doi.org/10.1007/s00289-021-03902-8
dc.identifier.urihttps://hdl.handle.net/11491/7246
dc.identifier.volume78en_US
dc.identifier.wosWOS:000702600200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBoran, Filiz
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPolymer Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPoly(vinyl alcohol)en_US
dc.subjectFreeze-thawingen_US
dc.subjectLong-term Stabilityen_US
dc.subjectSalicylic Aciden_US
dc.subjectDrug Releaseen_US
dc.titleThe influence of freeze-thawing conditions on swelling and long-term stability properties of poly(vinyl alcohol) hydrogels for controlled drug release
dc.typeArticle

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