Polycystic ovary syndrome and aging: Health implications after menopause

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dc.authoridYildiz, Bulent O. / 0000-0003-1797-7662
dc.authorwosidYildiz, Bulent O. / ABD-7781-2020
dc.contributor.authorHelvaci, Nafiye
dc.contributor.authorYildiz, Bulent Okan
dc.date.accessioned2021-11-01T15:03:15Z
dc.date.available2021-11-01T15:03:15Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractPolycystic ovary syndrome (PCOS) is a common endocrine disorder with heterogenous clinical manifestations. The evidence indicates that PCOS is associated with long-term health risks including type 2 diabetes, metabolic syndrome, obstructive sleep apnea, endometrial cancer, and mood disorders. Although cardiometabolic risk factors are more common among women with PCOS, currently there is no strong evidence for increased cardiovascular morbidity and mortality in these patients. The effect of menopausal transition on the long-term health consequences of PCOS is mostly uncertain. The PCOS phenotype improves with aging in affected women. Accordingly, the differences in the cardiometabolic risk profiles of PCOS patients and of the general population seem to disappear after menopause. However, it is not clear whether this phenotype amelioration is associated with changes in other long-term health risks after the menopause. There are also gaps in our knowledge about the impact of long-term use of oral contraceptives on the prevalence of PCOS-related comorbidities. This review summarizes the current knowledge regarding the long-term health consequences of PCOS and their clinical implications in peri- and postmenopause, and highlights areas for future research.
dc.identifier.doi10.1016/j.maturitas.2020.05.013
dc.identifier.endpage19en_US
dc.identifier.issn0378-5122
dc.identifier.issn1873-4111
dc.identifier.pmid32747035
dc.identifier.scopus2-s2.0-85085657687
dc.identifier.scopusqualityQ1
dc.identifier.startpage12en_US
dc.identifier.urihttps://doi.org/10.1016/j.maturitas.2020.05.013
dc.identifier.urihttps://hdl.handle.net/11491/7042
dc.identifier.volume139en_US
dc.identifier.wosWOS:000556763600003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofMaturitas
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPCOSen_US
dc.subjectObesityen_US
dc.subjectHypertensionen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectCanceren_US
dc.subjectDepressionen_US
dc.titlePolycystic ovary syndrome and aging: Health implications after menopause
dc.typeArticle

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