Analysis of Interleukin-1 Receptor Antagonist Variable Number Tandem Repeat Variant in Recurrent Aphthous Stomatitis

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dc.authoridTumer, Mehmet Kemal / 0000-0002-6250-0954
dc.authoridTEKCAN, AKIN / 0000-0001-7961-6657
dc.authoridYigit, Serbulent / 0000-0002-1019-3964
dc.authoridKURUCA, Nilufer / 0000-0001-5601-4952
dc.authoridNursal, Ayse Feyda / 0000-0001-7639-1122
dc.authorwosidTumer, Mehmet Kemal / R-3428-2019
dc.contributor.authorTekcan, Akin
dc.contributor.authorYigit, Serbulent
dc.contributor.authorNursal, Ayse F.
dc.contributor.authorTumer, Mehmet K.
dc.contributor.authorYerliyurt, Kaan
dc.contributor.authorKuruca, Nilufer
dc.date.accessioned2021-11-01T15:06:01Z
dc.date.available2021-11-01T15:06:01Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractBackground/Aims: Recurrent aphthous stomatitis (RAS) is one of the common oral inflammatory diseases. As immunological and genetic factors have been held responsible for the pathogenesis of RAS, the objective of this study was to determine whether the interleukin-1 receptor antagonist (IL-1Ra) gene variable number tandem repeat (VNTR) variant is a risk factor for the development of RAS in Turkish patients and to define its contribution to the increased risk. Methods: The IL-1Ra VNTR variant was evaluated in 169 RAS patients and 171 healthy controls by the polymerase chain reaction (PCR) method. Results: No statistically significant difference was found in the genotype distributions and allele frequencies of IL-1Ra VNTR variant between RAS patients and healthy controls. Conclusion: Lack of association between IL-1Ra VNTR variant and RAS could indicate that IL-1Ra has no significant role in the pathophysiology of RAS. However, it still appears to be very worthwhile to continue to search for cytokine gene variants in order to predict the development of such disease.
dc.identifier.doi10.2174/1871530320666200413092239
dc.identifier.endpage144en_US
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.issue1en_US
dc.identifier.pmid32282310
dc.identifier.scopus2-s2.0-85101153769
dc.identifier.scopusqualityQ2
dc.identifier.startpage139en_US
dc.identifier.urihttps://doi.org/10.2174/1871530320666200413092239
dc.identifier.urihttps://hdl.handle.net/11491/7469
dc.identifier.volume21en_US
dc.identifier.wosWOS:000613440100014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofEndocrine Metabolic & Immune Disorders-Drug Targets
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAphthous stomatitisen_US
dc.subjectproinflammatory cytokinesen_US
dc.subjectInterleukin-1 Receptor Antagonisten_US
dc.subjectpolymerase chain reactionen_US
dc.subjectvariable number tandem repeaten_US
dc.subjectvarianten_US
dc.titleAnalysis of Interleukin-1 Receptor Antagonist Variable Number Tandem Repeat Variant in Recurrent Aphthous Stomatitis
dc.typeArticle

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