Analytical application of polymethylene blue-multiwalled carbon nanotubes modified glassy carbon electrode on anticancer drug irinotecan and determination of its ionization constant value

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dc.authorid0000-0001-5469-9142
dc.authorid0000-0001-7494-3077
dc.contributor.authorKaradaş Bakırhan, Nurgül
dc.contributor.authorŞanlı, Senem
dc.contributor.authorAkmeşe, Bediha
dc.contributor.authorDoğan Topal, Burcu
dc.contributor.authorCan, Alp
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-10T09:39:17Z
dc.date.available2019-05-10T09:39:17Z
dc.date.issued2013
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractThe voltammetric behavior of anticancer drug irinotecan (IRT) was investigated at poly (methylene blue)/multi-walled carbon nanotube (PMB/MWCNT) modified glassy carbon electrode (GCE). The modified electrode surface was characterized by a scanning electron microscope (SEM). The PMB/MWCNT modified GCE exhibits a distinct shift of the oxidation potential of IRT on the cathodic direction and a considerable enhancement of the peak current compared with bare electrode. The calibration curve was linear between the concentration range 8.0×10-6 and 8.0×10-5 M with the detection limit of 2.14×10-7 M by differential pulse voltammetry in pH 10.0 Britton-Robinson buffer solution. Controlled potential coulometry was applied to find transferred electron numbers due to the oxidation of IRT. In this study, the pKa value of IRT was also determined by the dependence of the retention factor on the pH of the mobile phase. The effect of the mobile phase composition on the ionization constant was studied by measuring the pKa at different acetonitrile-water mixtures, ranging between 35 and 50% (v/v) using the reversed-phase liquid chromatography (RP-LC) method with UV detector. IRT was exposed to thermal, photolytic, hydrolytic and oxidative stress conditions, and the stressed samples were detected by the proposed method. Sensitive, rapid, and fully validated electrochemical and RP-LC methods for the determination of IRT in its dosage form were presented in details. © 2013 Elsevier B.V.
dc.identifier.citationKaradas, N., Sanli, S., Akmese, B., Dogan-Topal, B., Can, A., & Ozkan, S. A. (2013). Analytical application of polymethylene blue-multiwalled carbon nanotubes modified glassy carbon electrode on anticancer drug irinotecan and determination of its ionization constant value. Talanta, 115, 911-919.
dc.identifier.doi10.1016/j.talanta.2013.07.006
dc.identifier.endpage919en_US
dc.identifier.issn0039-9140
dc.identifier.scopusqualityQ1
dc.identifier.startpage911en_US
dc.identifier.urihttps://doi.org/10.1016/j.talanta.2013.07.006
dc.identifier.urihttps://hdl.handle.net/11491/660
dc.identifier.volume115en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofTalanta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarbon Nanotubesen_US
dc.subjectLonization Constanten_US
dc.subjectIrinotecanen_US
dc.subjectPoly (Methylene Blue)en_US
dc.subjectReversed-Phase Liquid Chromatographyen_US
dc.titleAnalytical application of polymethylene blue-multiwalled carbon nanotubes modified glassy carbon electrode on anticancer drug irinotecan and determination of its ionization constant value
dc.typeArticle

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