Blocking of L-type calcium channels protects hippocampal and nigral neurons against iron neurotoxicity: The role of L-type calcium channels in iron-induced neurotoxicity

Basit Öğe Kaydı
dc.contributor.authorBostancı, Mehmet Ömer
dc.contributor.authorBağırıcı, Faruk
dc.date.accessioned2019-05-10T09:38:54Z
dc.date.available2019-05-10T09:38:54Z
dc.date.issued2013
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractIron plays an important role in maintaining normal brain function. However, iron overload and enhanced hydroxyl radical formation have been implicated as the causative factors of some neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Calcium is also required for diverse physiological process including secretion of neurotransmitters, synaptic plasticity, gene expression and axonal growth. Iron and calcium are essential for neuronal function but, when present in excessive level, they induce neuronal damage and may even cause neuronal death. Some reports suggest that voltage gated calcium channels (VGCCs) are an alternate route for iron entry into neuronal cell lines under conditions of iron overload. The aim of the present study was to investigate the effects of L-type VGCCs on iron-induced neurotoxicity. Iron neurotoxicity was generated by intracerebroventricular FeCl3 injection. Nicardipine treatment (10 mg/kg/d) was applied to block L-type VGCCs for 10 d. Rats were perfused intracardially under deep urethane anaesthesia after treatment period. Removed brains were processed using the standard histological techniques. The numbers of neurons in hippocampus and substantia nigra of all rats were estimated by stereological techniques. Results of present study show that nicardipine decreased hippocampal and nigral neuron loss from 43.9% to 18.4% and 41.0% to 12.1%, respectively. Outcomes of the present study propose that blocking of L-type VGCCs may reduce the neurotoxic effects of iron by inhibiting the cellular influx of excessive calcium and/or iron ions. © 2013 Informa Healthcare USA, Inc.
dc.identifier.citationBostanci, M. Ö., Bagirici, F. (2013). Blocking of L-type calcium channels protects hippocampal and nigral neurons against iron neurotoxicity The role of L-type calcium channels in iron-induced neurotoxicity. International Journal of Neuroscience, 123(12), 876-882.
dc.identifier.doi10.3109/00207454.2013.813510
dc.identifier.endpage882en_US
dc.identifier.issn0020-7454
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage876en_US
dc.identifier.urihttps://doi.org/10.3109/00207454.2013.813510
dc.identifier.urihttps://hdl.handle.net/11491/537
dc.identifier.volume123en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofInternational Journal of Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHippocampusen_US
dc.subjectIronen_US
dc.subjectL-Type Calcium Channelen_US
dc.subjectNicardipineen_US
dc.subjectStereologyen_US
dc.subjectSubtantia Nigraen_US
dc.titleBlocking of L-type calcium channels protects hippocampal and nigral neurons against iron neurotoxicity: The role of L-type calcium channels in iron-induced neurotoxicity
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu