Serum progranulin levels are elevated in infertile women with obesity

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dc.authorid0000-0002-2887-1073
dc.contributor.authorGörkem, Ümit
dc.contributor.authorÖztürk İnal, Zeynep
dc.contributor.authorİnal, Hasan Ali
dc.contributor.authorBostancı, Mehmet Ömer
dc.date.accessioned2019-05-13T09:08:11Z
dc.date.available2019-05-13T09:08:11Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractIntroduction: The aim of the present study was to investigate the changes in serum progranulin and sex hormone levels in infertile women with obesity. Material and methods: A total of 171 infertile women who had fertility desire were included in this cross-sectional study. The initial assessment included measurements of weight, height, waist circumference, and hip circumference to calculate body mass index (BMI) and waist/hip ratio. All participants were categorised into two groups in accordance with BMI as a control group (< 30 kg/m2, n = 135) and a study group (? 30 kg/m2, n = 36). After anthropometric measurements, venous blood samples were taken for analyses of oestradiol and follicle stimulating hormone (FSH), luteinising hormone, total testosterone (TT), 17-hydroxyprogesterone, dehydroepiandrosterone sulphate, anti-Müllerian hormone, and progranulin. Results: The present study demonstrated that the overweight women had higher FSH levels (p < 0.01). Elevated TT levels were detected in obese women (p < 0.05). Progranulin concentrations were higher in the study group than in the control group (p < 0.05). Regression analysis demonstrated that there was a relationship between the serum progranulin concentrations and BMI (p < 0.05). Conclusions: Our findings support that the elevated progranulin levels are associated with obesity in infertile women. Therefore, infertile and obese patients may benefit if their serum progranulin levels decrease. Further studies are needed to elucidate this issue. ? 2018 Endokrynologia Polska. All rights reserved.
dc.description.abstractWst?p: Celem badania by?a analiza zmian st??e? progranuliny i hormonów p?ciowych u bezp?odnych kobiet z oty?o?ci?. Materia? i metody: Do przekrojowego badania w??czono 171 bezp?odnych kobiet, które chcia?y zaj?? w ci???. Ocena wst?pna obejmowa?a pomiary masy cia?a, wzrostu, obwodu talii i bioder w celu obliczenia wska?nika masy cia?a (BMI) i wspó?czynnika talia/biodra. Wszystkie uczestniczki podzielono na dwie grupy w zale?no?ci od warto?ci BMI, tworz?c grup? kontroln? (< 30 kg/m2 , n = 135) oraz grup? badan? (? 30 kg/m2 , n = 36). Po wykonaniu pomiarów antropometrycznych od wszystkich kobiet pobrano próbki krwi ?ylnej do oznacze? st??e? estradiolu i hormonu folikulotropowego (FSH), hormonu luteinizuj?cego, testosteronu ca?kowitego (TT), 17-hydroksyprogesteronu, siarczanu dehydroepiandrosteronu, hormonu antymüllerowskiego i progranuliny. Wyniki: W badaniu wykazano, ?e u oty?ych kobiet st??enie FSH jest podwy?szone (p < 0,01). W tej grupie kobiet stwierdzono równie? podwy?szone st??enie TT (p < 0,05). St??enie progranuliny by?o wy?sze w grupie badanej ni? w grupie kontrolnej (p < 0,05). W analizie regresji wykazano zale?no?? mi?dzy st??eniem progranuliny w surowicy a BMI (p < 0,05). Wnioski: Uzyskane wyniki potwierdzaj?, ?e u bezp?odnych kobiet podwy?szone st??enie progranuliny wi??e si? z oty?o?ci?. Dlatego obni?enie st??enia progranuliny w surowicy mo?e przynie?? korzystne efekty u kobiet z bezp?odno?ci? i oty?o?ci?. Potrzebne s? dalsze badania w tej dziedzinie. (Endokrynol Pol 2018; 69 (6): 661–666)
dc.identifier.citationGörkem, Ü., Öztürk İnal, Z., İnal, H. İ., Bostancı, M. Ö. (2018). Serum progranulin levels are elevated in infertile women with obesity. Endokrynologia Polska, 69(6), 661-666.
dc.identifier.doi10.5603/EP.a2018.0044
dc.identifier.endpage666en_US
dc.identifier.issn0423-104X
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage661en_US
dc.identifier.urihttps://doi.org/10.5603/EP.a2018.0044
dc.identifier.urihttps://hdl.handle.net/11491/1953
dc.identifier.volume69en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofEndokrynologia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectProgranulinen_US
dc.subjectGranulinen_US
dc.subjectObesityen_US
dc.subjectInfertilityen_US
dc.subjectProgranulinaen_US
dc.subjectGranulinaen_US
dc.subjectOtyłośćen_US
dc.subjectBezpłodnośćen_US
dc.titleSerum progranulin levels are elevated in infertile women with obesity
dc.title.alternativePodwy?szone st??enia progranuliny w surowicy bezp?odnych kobiet z oty?o?ci?en_US
dc.typeArticle

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