Novel palladium (II) complexes of N-(5-nitro-salicylidene)-Schiffbases: Synthesis, spectroscopic characterization and cytotoxicity investigation

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dc.authorid0000-0002-8248-0268
dc.contributor.authorÖzdemir, Özlem
dc.contributor.authorGürkan, Perihan
dc.contributor.authorArk, Mustafa
dc.contributor.authorŞimay Demir, Yaprak Dilber
dc.date.accessioned2020-02-25T07:13:58Z
dc.date.available2020-02-25T07:13:58Z
dc.date.issued2020en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractA series of palladium(II) complexes (1ee3e) with the general formulae [Pd(L)(H2O)]$xH2O were newlysynthesized by the interaction of palladium(II) chloride and the monosodium salts ofN-(5-nitro-sali-cylidene)-Schiff base ligands (1ae3a) in aqueous DMF solution. The identities of all the complexes wereproven by elemental analysis, FTIR,1H,13CNMR,LCeMS, UVevis, XPS, powder XRD spectra, thermalanalysis, conductivity and magnetic susceptibility measurements. The obtained analytical and physico-chemical results exhibited a square-planar coordination of the palladium(II) ion having a doubledeprotonated ligand and a coordinated water molecule.In vitrocytotoxicity of these Pd(II) complexeswas screened against tumor cell lines (HeLa and MCF-7), and a normal human cell line (HEK-293). Thecomplexes 1e and 2e exhibited a moderate antitumor activity against HeLa cell lines, while 3e had betteractivity than standard anticancer drug, doxorubicin. All three complexes showed the best active cyto-toxicity than doxorubicin against MCF-7 cancer lines. For HEK-293 lines, a decrease in concentration ofthe complexes significantly decreased their toxicity.
dc.description.provenanceSubmitted by Zeynep Umut Arslan (umutarslan@hitit.edu.tr) on 2020-02-25T07:13:43Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Zeynep Umut Arslan (umutarslan@hitit.edu.tr) on 2020-02-25T07:13:58Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-02-25T07:13:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.citationÖzdemir, Ö., Gürkan, P., Demir, Y. D. Ş., Ark, M. (2020). Novel palladium (II) complexes of N-(5-nitro-salicylidene)-Schiff bases: Synthesis, spectroscopic characterization and cytotoxicity investigation. Journal of Molecular Structure, 1207.
dc.identifier.doi10.1016/j.molstruc.2020.127852
dc.identifier.issn0022-2860
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2020.127852
dc.identifier.urihttps://hdl.handle.net/11491/5760
dc.identifier.volume1207en_US
dc.identifier.wosWOS:000517790600072
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSchiff Basesen_US
dc.subjectPalladium (II) Complexesen_US
dc.subjectCytotoxicityen_US
dc.subjectHeLaen_US
dc.subjectMCF-7en_US
dc.subjectHEK-293en_US
dc.titleNovel palladium (II) complexes of N-(5-nitro-salicylidene)-Schiffbases: Synthesis, spectroscopic characterization and cytotoxicity investigation
dc.typeArticle

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