Simultaneous estimation and validation of some binary mixtures of antihypertensive drugs by RP-LC methods using two new generation silica columns
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Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Two reversed phase liquid chromatographic (RP-LC) techniques are presented for the rapid, accurate, precise, simultaneous determination of olmesartan-hydrochlorothiazide and zofenopril-hydrochlorothiazide binary mixtures in their dosage forms. The separation of these binary mixtures was carried out by using two new stationary phases that have different surface chemistries which were used for the first time in the determination of these binary mixtures. The analyte peaks were detected at 216nm. Linearity was obtained in different concentration ranges between 0.5 and 20?gmL-1 for all compounds. The proposed methods have been extensively validated and sample preparation, flow rate, run time of the analytical systems were at low levels. The proposed methods would decrease the consumption of organic solvents and reagents further safeguarding to our environment. © 2012 Elsevier B.V.
Açıklama
Anahtar Kelimeler
Hydrochlorothiazide, LC, New Generation Columns, Olmesartan, Zofenopril
Kaynak
Journal of Pharmaceutical and Biomedical Analysis
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
72
Sayı
Künye
Kurbanoğlu, S., Gümüştaş, M., Özkan, S. A. (2013). Simultaneous estimation and validation of some binary mixtures of antihypertensive drugs by RP-LC methods using two new generation silica columns. Journal of Pharmaceutical and Biomedical Analysis, 72, 198-201.
