Simultaneous estimation and validation of some binary mixtures of antihypertensive drugs by RP-LC methods using two new generation silica columns

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dc.contributor.authorKurbanoğlu, Sevinç
dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorÖzkan, A. S.
dc.date.accessioned2019-05-13T08:57:40Z
dc.date.available2019-05-13T08:57:40Z
dc.date.issued2013
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractTwo reversed phase liquid chromatographic (RP-LC) techniques are presented for the rapid, accurate, precise, simultaneous determination of olmesartan-hydrochlorothiazide and zofenopril-hydrochlorothiazide binary mixtures in their dosage forms. The separation of these binary mixtures was carried out by using two new stationary phases that have different surface chemistries which were used for the first time in the determination of these binary mixtures. The analyte peaks were detected at 216nm. Linearity was obtained in different concentration ranges between 0.5 and 20?gmL-1 for all compounds. The proposed methods have been extensively validated and sample preparation, flow rate, run time of the analytical systems were at low levels. The proposed methods would decrease the consumption of organic solvents and reagents further safeguarding to our environment. © 2012 Elsevier B.V.
dc.identifier.citationKurbanoğlu, S., Gümüştaş, M., Özkan, S. A. (2013). Simultaneous estimation and validation of some binary mixtures of antihypertensive drugs by RP-LC methods using two new generation silica columns. Journal of Pharmaceutical and Biomedical Analysis, 72, 198-201.
dc.identifier.doi10.1016/j.jpba.2012.08.018
dc.identifier.endpage201en_US
dc.identifier.issn0731-7085
dc.identifier.scopusqualityQ1
dc.identifier.startpage198en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpba.2012.08.018
dc.identifier.urihttps://hdl.handle.net/11491/980
dc.identifier.volume72en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHydrochlorothiazideen_US
dc.subjectLCen_US
dc.subjectNew Generation Columnsen_US
dc.subjectOlmesartanen_US
dc.subjectZofenoprilen_US
dc.titleSimultaneous estimation and validation of some binary mixtures of antihypertensive drugs by RP-LC methods using two new generation silica columns
dc.typeArticle

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