Effect of high-risk human papillomavirus in esophageal squamous cell carcinoma in Somalian and Turkish cases

Basit Öğe Kaydı
dc.authoridBas, Yilmaz / 0000-0002-4229-8568
dc.contributor.authorBaş, Yılmaz
dc.contributor.authorVardar Aker, Fügen
dc.contributor.authorGönültaş, Aylin
dc.contributor.authorAkdeniz, Raşit
dc.contributor.authorTurgal, Ebru
dc.contributor.authorArar Çıkrıkçıoğlu, Makbule
dc.date.accessioned2021-11-01T15:02:04Z
dc.date.available2021-11-01T15:02:04Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractThis study aimed to investigate the role of high-risk human papillomavirus (Hr-HPV) in Somalian and Turkish patients with esophageal squamous cell carcinoma (ESCC). In the sections obtained from paraffin-embedded blocks, the results of invasive tumor, peripheral tumor dysplasia and normal mucosa were examined. Samples containing 45 and 47 ESCC, 46 and 42 dysplasia in Somalian (n = 52) and Turkish (n = 53) cases, respectively, were included in the study. We examined the presence of 14 types of Hr-HPV in ESCC collected from Somalia and Turkey by Aptima (R) Panther System. Hr-HPV types were not detected in Somalian cases. p16INK4a is positive in 5 (11.4%) tumors and 6 (13%) dysplasia. p53 is positive in 28 (62.2%) tumors and 35 (76.1%) dysplasia. HPV16-18/45 are positive only in one of the Turkish cases. p16INK4a is positive in 5 (10.6%) tumors and 4 (9.5%) dysplasia. p53 is positive in 31 (63.3%) tumors and 24 (57.1%) dysplasia. No reaction was detected in normal mucosa samples in both countries. This study is regional. Although the findings did not reflect the general population, the present study shows that the effect of HPV on carcinogenesis in Somalian and Turkish ESCC patients was not significant.
dc.identifier.doi10.1093/femspd/ftz047
dc.identifier.issn2049-632X
dc.identifier.issue5en_US
dc.identifier.pmid31504479
dc.identifier.scopus2-s2.0-85072588235
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1093/femspd/ftz047
dc.identifier.urihttps://hdl.handle.net/11491/6833
dc.identifier.volume77en_US
dc.identifier.wosWOS:000497975900003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBaş, Yılmaz
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofPathogens And Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectesophagusen_US
dc.subjectsquamous cell carcinomaen_US
dc.subjecthuman papillomavirusen_US
dc.subjectp16en_US
dc.subjectp53en_US
dc.titleEffect of high-risk human papillomavirus in esophageal squamous cell carcinoma in Somalian and Turkish cases
dc.typeArticle

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