Ischemia-modified albumin as a possible marker of oxidative stress in patients with telogen effluvium

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dc.authoridEREL, Ozcan / 0000-0002-2996-3236
dc.authoridSenel, Engin / 0000-0001-8098-1686
dc.authoridSungur, Sana / 0000-0001-7370-8972
dc.authorwosidSenel, Engin / A-1516-2009
dc.authorwosidSungur, Sana / P-9247-2018
dc.contributor.authorSavcı, Ünsal
dc.contributor.authorŞenel, Engin
dc.contributor.authorÖztekin, Aynure
dc.contributor.authorSungur, Mustafa
dc.contributor.authorErel, Özcan
dc.contributor.authorNeşelioğlu, Salim
dc.date.accessioned2021-11-01T15:03:12Z
dc.date.available2021-11-01T15:03:12Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractBackground: Telogen effluvium is the most common form of non-scarring alopecia characterized by diffuse hair loss. Ischemia-modified albumin is a marker of oxidative stress and inflammation. Objective: The aim of this study was to compare the levels of ischemia-modified albumin of telogen effluvium patients with healthy controls. Methods: Ninety-one patients diagnosed with telogen effluvium and 35 healthy volunteers were included in the study. Serum ischemia-modified albumin level was determined by a fast-colorimetric method, and albumin cobalt binding test. The results were evaluated statistically. Results: There was no statistically significant difference between the serum albumin values of patient and control groups (p = 0.739). Serum ischemia-modified albumin values were significantly higher in the patients with telogen effluvium than healthy controls (p < 0.001). Study limitations: Body mass index values of the patient and control groups could not be calculated. Conclusions: To the best of the authors' knowledge, this is the first clinical study to investigate the role of oxidative stress in the pathogenesis of telogen effluvium using ischemia-modified albumin as a biomarker. Based on the results of the present study, it can be considered that oxidative stress plays an important role in the pathogenesis of telogen effluvium. There is a need for further studies to support the results of this study, to demonstrate the possible effects of oxidative stress, and to investigate the other oxidative stress markers in the pathogenesis of telogen effluvium. (C) 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U.
dc.identifier.doi10.1016/j.abd.2020.01.005
dc.identifier.endpage451en_US
dc.identifier.issn0365-0596
dc.identifier.issn1806-4841
dc.identifier.issue4en_US
dc.identifier.pmid32482549
dc.identifier.scopus2-s2.0-85085599745
dc.identifier.scopusqualityQ2
dc.identifier.startpage447en_US
dc.identifier.urihttps://doi.org/10.1016/j.abd.2020.01.005
dc.identifier.urihttps://hdl.handle.net/11491/7023
dc.identifier.volume95en_US
dc.identifier.wosWOS:000546311100005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞenel, Engin
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofAnais Brasileiros De Dermatologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlopeciaen_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.titleIschemia-modified albumin as a possible marker of oxidative stress in patients with telogen effluvium
dc.typeArticle

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