The effects of dexmedetomidine in increased intestinal permeability after traumatic brain injury: An experimental study
Yükleniyor...
Dosyalar
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Association of Trauma and Emergency Surgery
Erişim Hakkı
Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
BACKGROUND: This study aims to investigate whether or not dexmedetomidine (DEX) application affects inflammation, increased intestinal mucosa damage and intestinal permeability in traumatic brain injury (TBI). METHODS: The rats included in our study were randomized into three groups as the control group (Group 1, n=10), trauma group (Group 2, n=10) and the trauma+dexmedetomidine group (Group 3, n=10). While trauma was not induced in the control group, head trauma was induced in all rats in Groups 2 and 3 with the same method. The rats in Group 3 additionally received the DEX application. Intestinal THF-a, serum TNF-a, IL-6, IL-1b and D-lactate levels were measured six hours post-trauma to assess systemic and local infection. Histopathological evaluation of the terminal ileum was performed at the 6th hour to assess mucosal damage. Intestinal permeability was evaluated by measuring the level of dextran injected into the 5-cm ileum segment adhered to the proximal and distal edges at the 30th minute in the blood taken by cardiac puncture. RESULTS: Intestinal TNF-a (p=0.003), serum TNF-a (p=0.009), IL-6 (p=0.002), IL-1b (p=0.001), and D-lactate levels measured in Group 3 (p=0.046) were significantly lower than those measured in Group 2. Dextran level measured in blood in Group 3 was observed significantly lower than that of Group 2 (p
Açıklama
Anahtar Kelimeler
Dexmedetomidine, Intestinal Mucosa Damage, Intestinal Permeability, Traumatic Brain Injury
Kaynak
Turkish Association of Trauma and Emergency Surgery-Ulusal Travma ve Acil Cerrahi Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
26
Sayı
1
Künye
Karaca, O., Doğan, G. (2020). The effects of dexmedetomidine in increased intestinal permeability after traumatic brain injury: An experimental study. Ulus Travma Acil Cerrahi Derg, 26(1): 15-20.
