The effects of dexmedetomidine in increased intestinal permeability after traumatic brain injury: An experimental study
| dc.authorid | 0000-0002-3339-4195 | |
| dc.authorid | 0000-0001-7351-8968 | |
| dc.contributor.author | Karaca, Onur | |
| dc.contributor.author | Doğan, Güvenç | |
| dc.date.accessioned | 2020-02-03T08:45:26Z | |
| dc.date.available | 2020-02-03T08:45:26Z | |
| dc.date.issued | 2020 | en_US |
| dc.department | Hitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | |
| dc.description.abstract | BACKGROUND: This study aims to investigate whether or not dexmedetomidine (DEX) application affects inflammation, increased intestinal mucosa damage and intestinal permeability in traumatic brain injury (TBI). METHODS: The rats included in our study were randomized into three groups as the control group (Group 1, n=10), trauma group (Group 2, n=10) and the trauma+dexmedetomidine group (Group 3, n=10). While trauma was not induced in the control group, head trauma was induced in all rats in Groups 2 and 3 with the same method. The rats in Group 3 additionally received the DEX application. Intestinal THF-a, serum TNF-a, IL-6, IL-1b and D-lactate levels were measured six hours post-trauma to assess systemic and local infection. Histopathological evaluation of the terminal ileum was performed at the 6th hour to assess mucosal damage. Intestinal permeability was evaluated by measuring the level of dextran injected into the 5-cm ileum segment adhered to the proximal and distal edges at the 30th minute in the blood taken by cardiac puncture. RESULTS: Intestinal TNF-a (p=0.003), serum TNF-a (p=0.009), IL-6 (p=0.002), IL-1b (p=0.001), and D-lactate levels measured in Group 3 (p=0.046) were significantly lower than those measured in Group 2. Dextran level measured in blood in Group 3 was observed significantly lower than that of Group 2 (p | |
| dc.description.provenance | Submitted by Zeynep Umut Arslan (umutarslan@hitit.edu.tr) on 2020-02-03T08:45:13Z No. of bitstreams: 2 guvenc-dogan2020.pdf: 2842867 bytes, checksum: 5c9a9c8f92bcafacb5fc372c196f2403 (MD5) license_rdf: 1030 bytes, checksum: 016d5c38d05c8fdbfdbc3c4d500be754 (MD5) | en |
| dc.description.provenance | Approved for entry into archive by Zeynep Umut Arslan (umutarslan@hitit.edu.tr) on 2020-02-03T08:45:26Z (GMT) No. of bitstreams: 2 guvenc-dogan2020.pdf: 2842867 bytes, checksum: 5c9a9c8f92bcafacb5fc372c196f2403 (MD5) license_rdf: 1030 bytes, checksum: 016d5c38d05c8fdbfdbc3c4d500be754 (MD5) | en |
| dc.description.provenance | Made available in DSpace on 2020-02-03T08:45:26Z (GMT). No. of bitstreams: 2 guvenc-dogan2020.pdf: 2842867 bytes, checksum: 5c9a9c8f92bcafacb5fc372c196f2403 (MD5) license_rdf: 1030 bytes, checksum: 016d5c38d05c8fdbfdbc3c4d500be754 (MD5) Previous issue date: 2020 | en |
| dc.identifier.citation | Karaca, O., Doğan, G. (2020). The effects of dexmedetomidine in increased intestinal permeability after traumatic brain injury: An experimental study. Ulus Travma Acil Cerrahi Derg, 26(1): 15-20. | |
| dc.identifier.doi | 10.14744/tjtes.2019.49768 | |
| dc.identifier.endpage | 20 | en_US |
| dc.identifier.issn | 1306-696X | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 15 | en_US |
| dc.identifier.uri | http://www.tjtes.org/eng/jvi.aspx?pdir=travma&plng=eng&un=UTD-49768 | |
| dc.identifier.uri | https://hdl.handle.net/11491/5679 | |
| dc.identifier.volume | 26 | en_US |
| dc.identifier.wos | WOS:000507495500003 | |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Turkish Association of Trauma and Emergency Surgery | |
| dc.relation.ispartof | Turkish Association of Trauma and Emergency Surgery-Ulusal Travma ve Acil Cerrahi Dergisi | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
| dc.subject | Dexmedetomidine | en_US |
| dc.subject | Intestinal Mucosa Damage | en_US |
| dc.subject | Intestinal Permeability | en_US |
| dc.subject | Traumatic Brain Injury | en_US |
| dc.title | The effects of dexmedetomidine in increased intestinal permeability after traumatic brain injury: An experimental study | |
| dc.title.alternative | Travmatik beyin hasarında artmış bağırsak geçirgenliğine deksmedetomidinin etkisi: Deneysel çalışma | en_US |
| dc.type | Article |
