Prognostic value of neglected biomarker in sepsis patients with the old and new criteria: predictive role of lactate dehydrogenase

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dc.contributor.authorDuman, Ali
dc.contributor.authorAköz, Ayhan
dc.contributor.authorKapcı, Mücahit
dc.contributor.authorTüre, Mevlüt
dc.contributor.authorÖrün, Serhat
dc.contributor.authorKaraman, Kıvanç
dc.contributor.authorTürkdoğan, Kenan Ahmet
dc.date.accessioned2019-05-13T08:57:42Z
dc.date.available2019-05-13T08:57:42Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjectives This study examined the pH, lactate dehydrogenase (LDH), and heart rate values on the first day of hospitalization in patients with a prediagnosis of sepsis and biomarkers that may predict mortality. Methods Patients hospitalized in an emergency intensive care unit with a diagnosis of systemic inflammatory response syndrome were classified as having sepsis (n = 28), septic shock (n = 8), or severe sepsis (n = 8) according to International Sepsis Guidelines (old criteria). Forty-four patients were classified as having sepsis (n = 4), septic shock (n = 30), or infection (n = 10) according to The Third International Consensus Definitions for Sepsis and Septic Shock (new criteria). The effects of these patients' laboratory values on survival between groups were compared. Significant values were evaluated by ?2 automatic interaction detection analysis. Results When the patients were categorized according to the new classification criteria, there was an increase in the number of septic shock patients and a decrease in the number of sepsis patients. In addition, 10 patients were removed from the sepsis category. There was a significant difference between ex and discharged patients in terms of heart rate, pH, sodium bicarbonate, lactate, and LDH (P=.007, P=.002, P=.034, P=.009, and P=.002, respectively). Based on a ?2 automatic interaction detection analysis of the significant values, pH, LDH, and heart rate were prominent predictors of prognosis. Conclusions Systemic pH, LDH, and heart rate values may be used to determine the best time to discharge patients from intensive care to other, more affordable hospital units. © 2016 Elsevier Inc.
dc.identifier.citationDuman, A., Aköz, A., Kapcı, M., Türe, M., Örün, S., Karaman, K., Türkdogan, K. A. (2016). Prognostic value of neglected biomarker in sepsis patients with the old and new criteria: predictive role of lactate dehydrogenase. American Journal of Emergency Medicine, 34(11), 2167-2171.
dc.identifier.doi10.1016/j.ajem.2016.06.012
dc.identifier.endpage2171en_US
dc.identifier.issn0735-6757
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage2167en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajem.2016.06.012
dc.identifier.urihttps://hdl.handle.net/11491/990
dc.identifier.volume34en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW.B. Saunders
dc.relation.ispartofAmerican Journal of Emergency Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titlePrognostic value of neglected biomarker in sepsis patients with the old and new criteria: predictive role of lactate dehydrogenase
dc.typeArticle

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