Interaction between carbenoxolone and valproic acid on pentylenetetrazole kindling model of epilepsy

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dc.contributor.authorSefil, Fatih
dc.contributor.authorArık, Aliye E.
dc.contributor.authorAcar, Meryem D.
dc.contributor.authorBostancı, Mehmet Ömer
dc.contributor.authorBağırıcı, Faruk
dc.contributor.authorKozan, Ramazan
dc.date.accessioned2019-05-13T09:07:23Z
dc.date.available2019-05-13T09:07:23Z
dc.date.issued2015
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractGap junctions play an important role in the synchronized neuronal discharges. The main reason of the epileptic seizures is disruption of this synchronization. Therefore, the aim of the present study is to explore the combination valproic acid with carbenoxolone in pentylenetetrazole-kindled rats. In the first set of experiments, pentylenetetrazole (35 mg/kg intraperitoneally was administered to the rats to produce the kindling and then permanent screw electrodes to record electroencephalographic signals. The kindled rats were divided into six groups. While electroencephalographic recordings received from animals, behavioral evaluation was done by an observer. The data analysis was performed using T test and Mann-Whitney U tests. The dose of 40 mg/kg carbenoxolone was the most effective in carbenoxolone treatment groups. It prevented generalized seizures by 50%, reduced seizure stage, seizure duration and spike frequency. There was no significant difference between carbenoxolone-valproic acid combination and valproic acid on any seizure parameters. The current study is the first study which shows the interaction of carbenoxolone with valproic acid in pentylenetetrazole kindling model. As a result, carbenoxolone-valproic acid combination was not more effective than the standalone use of these drugs. © 2015 E-Century Publishing Corporation. All rights reserved.
dc.identifier.citationSefil, F., Arık, A. E., Acar, M. D., Bostancı, M. Ö., Bagirici, F., & Kozan, R. (2015). Interaction between carbenoxolone and valproic acid on pentylenetetrazole kindling model of epilepsy. International journal of clinical and experimental medicine, 8(7), 10508.
dc.identifier.endpage10514en_US
dc.identifier.issn1940-5901
dc.identifier.issue7en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage10508en_US
dc.identifier.urihttps://hdl.handle.net/11491/1789
dc.identifier.volume8en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherE-Century Publishing Corporation
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarbenoxoloneen_US
dc.subjectEpilepsyen_US
dc.subjectGap Junctionen_US
dc.subjectKindling Modelen_US
dc.subjectValproic Aciden_US
dc.titleInteraction between carbenoxolone and valproic acid on pentylenetetrazole kindling model of epilepsy
dc.typeArticle

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