Effect of a functional variant of tumor necrosis factor-? gene in temporomandibular disorders: a pilot study
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Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Inc.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Temporomandibular disorders (TMD) are a group of conditions that cause chronic orofacial pain. The tumor necrosis factor ? (TNF-?) is a proinflammatory cytokine that is involved in the various aspects of the inflammatory process including organization and maintenance, and in the arrangement of cells at the inflammation site. The purpose of this study was to evaluate the correlation between TNF-? +252A/G (rs909253) variant and susceptibility to TMD in a Turkish cohort. Methods: The study included 104 patients (26 males, 78 females) with TMD and 126 healthy controls (44 males, 82 females). The TNF-? +252A/G variant analysis was based on Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: There was no deviation from HWA for TNF-? +252A/G variant in patient and control groups. There was significant difference in genotype and allele frequencies between patient group and control group in terms of TNF-? +252A/G variant, respectively (P = 0.010, 0.015). A significant increase in the TNF-? +252 AG genotype and G allele frequencies were observed in TMD patients compared to healthy controls. The individuals with GG genotype and G allele had an increased risk of developing TMD. A statistically significant association was observed when the patients were compared with the controls according to AA genotype vs AG+GG genotypes (P = 0.002, OR: 2.23, 95% CI:1.31-3.82). TNF-? +252A/G genotype distribution was associated with chewing problems (P = 0.046). Conclusions: In conclusion, our results provided evidence that TNF-? +252A/G variant may contribute to TMD development in a Turkish cohort. Further studies are needed to confirm this observation. © 2018 Wiley Periodicals, Inc.
Açıklama
Anahtar Kelimeler
+252A/G, Temporomandibular Disorders, Tumor Necrosis Factor β, Variant
Kaynak
Journal of Clinical Laboratory Analysis
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
33
Sayı
1
Künye
Yerliyurt, K., Nursal, A F , Tekcan, A., Karakuş, N., Tümer, M. K., Yiğit, S. (2019). Effect of a functional variant of tumor necrosis factor-? gene in temporomandibular disorders: a pilot study. Journal of Clinical Laboratory Analysis, 33(1).
