Cardiovascular evaluation of pregnant women with hypertrophic cardiomyopathy

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dc.contributor.authorGüner, Ahmet
dc.contributor.authorCandan, Özkan
dc.contributor.authorKahraman, Serkan
dc.contributor.authorGültekin Güner, Ezgi
dc.contributor.authorKalçık, Macit
dc.date.accessioned2024-01-25T12:26:57Z
dc.date.available2024-01-25T12:26:57Z
dc.date.issued2023en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: The effect of physiological circulatory changes during pregnancy on hypertrophic cardiomyopathy (HCM) has been reported with limited data. This study aimed to provide information regarding outcomes of pregnant women with HCM and to identify predictors of major adverse cardiac event (MACE). Methods: A total of 45 pregnancies with HCM were retrospectively reviewed. The primary endpoint was a MACE that occurred within an 8-week period after delivery, including maternal death, heart failure (HF), syncope, and malignant ventricular arrhythmias (VAs). Baseline and outcome data were analyzed for all patients. Patients with and without MACE were compared, and patients with obstructive HCM were compared with those who had non-obstructive HCM. The study population was divided into two subgroups of patients having or not having an implantable cardioverter defibrillator implantation (ICD). Results: At least one MACE occurred in 11 patients (24.4%); six patients developed HF (13.3%), six had a ventricular tachyarrhythmia (13.3%), and two had syncope (4.4%). New York Heart Association functional class of ? II, presence of HF signs before pregnancy, increased left ventricular outflow tract (LVOT) gradient were significantly associated with MACE. Fatal VAs were seen during pregnancy in one of five HCM patients with ICD. In the ROC curve analysis, an LVOT gradient higher than 53.5 mm Hg predicted the presence of MACE with a sensitivity of 90.9% and a specificity of 73.5%. This study is the largest series in the literature representing pregnant women who had HCM and ICD. Conclusion: The current data suggest that HF and high LVOT gradients are important risk factors for the development of cardiac complications.
dc.description.provenanceSubmitted by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-01-25T12:26:46Z No. of bitstreams: 0en
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dc.description.provenanceMade available in DSpace on 2024-01-25T12:26:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2023en
dc.identifier.citationGüner, A., Candan, Ö., Kahraman, S., Güner, E. G., Özcan, S., Gürsoy, M. O., ... & Özkan, M. (2023). Cardiovascular evaluation of pregnant women with hypertrophic cardiomyopathy. Herz, 48(2), 141-151.
dc.identifier.doi10.1007/s00059-022-05108-8
dc.identifier.issn0340-9937
dc.identifier.issn1615-6692
dc.identifier.pmid35364724
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1007/s00059-022-05108-8
dc.identifier.urihttps://hdl.handle.net/11491/8744
dc.identifier.wosWOS:000777240800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKalçık, Macit
dc.language.isoen
dc.publisherURBAN & VOGEL
dc.relation.ispartofHERZ
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHypertrophic cardiomyopathyen_US
dc.subjectPregnancyen_US
dc.subjectVentricular arrhythmiaen_US
dc.subjectHeart failureen_US
dc.subjectSyncopeen_US
dc.titleCardiovascular evaluation of pregnant women with hypertrophic cardiomyopathy
dc.typeArticle

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