Investigation of pregnancy-associated malaria by microscopy, rapid diagnostic test and PCR in Bandundu, the Democratic Republic of Congo
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Oxford University Press
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The study was conducted to investigate malaria prevalence among a group of women in the Democratic Republic of Congo (DRC) who received intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP). Methods: A total of 250 women from Bandundu city who received two doses of IPTp-SP were enrolled in the survey. Blood samples were collected at the time of delivery and malaria prevalence was determined using microscopy, rapid diagnostic test (RDT), and nested polymerase chain reaction (PCR). Results: Malaria infection was detected in 81 (32.4%), 93 (37.2%), and 92 (36.8%) samples by microscopy, RDT, and PCR, respectively. Among 92 samples, P. falciparum mono-infection (n=87; 94.5%), P. falciparum+P. vivax (n=2; 2.2%) and P. falciparum+P. malariae (n=1; 1.1%) mixed infections, and P. vivax mono-infection (n=2; 2.2%) were detected. Prevalence of malaria was not affected by age and number of pregnancies (p<0.05). Microscopy and RDT, either alone ( ?=0.29; p<0.001) or in combination (?=0.33; p<0.001) showed a fair agreement with PCR. Conclusions: Our findings indicate that two doses of IPTp-SP did not protect the women against malaria in the DRC, and support the World Health Organization (WHO) guidelines that ensure a minimum of three doses of SP in pregnancy. © The Author(s) 2018. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved.
Açıklama
Anahtar Kelimeler
Democratic Republic of Congo, Microscopy, PCR, Pregnancy, Rapid Diagnostic Test, Malaria
Kaynak
Transactions of the Royal Society of Tropical Medicine and Hygiene
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
112
Sayı
1
Künye
Ruh, E., Bateko, J. P., Imir, T., & Taylan-Ozkan, A. (2018). Investigation of pregnancy-associated malaria by microscopy, rapid diagnostic test and PCR in Bandundu, the Democratic Republic of Congo. Transactions of The Royal Society of Tropical Medicine and Hygiene, 112(1), 8-13.
