Investigation of pregnancy-associated malaria by microscopy, rapid diagnostic test and PCR in Bandundu, the Democratic Republic of Congo

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dc.authorid0000-0001-8421-3625
dc.contributor.authorRuh, Emrah
dc.contributor.authorBateko, Jean Paul
dc.contributor.authorImir, Turgut
dc.contributor.authorTaylan Özkan, Hikmet Ayşegül
dc.date.accessioned2019-05-10T09:39:16Z
dc.date.available2019-05-10T09:39:16Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground: The study was conducted to investigate malaria prevalence among a group of women in the Democratic Republic of Congo (DRC) who received intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP). Methods: A total of 250 women from Bandundu city who received two doses of IPTp-SP were enrolled in the survey. Blood samples were collected at the time of delivery and malaria prevalence was determined using microscopy, rapid diagnostic test (RDT), and nested polymerase chain reaction (PCR). Results: Malaria infection was detected in 81 (32.4%), 93 (37.2%), and 92 (36.8%) samples by microscopy, RDT, and PCR, respectively. Among 92 samples, P. falciparum mono-infection (n=87; 94.5%), P. falciparum+P. vivax (n=2; 2.2%) and P. falciparum+P. malariae (n=1; 1.1%) mixed infections, and P. vivax mono-infection (n=2; 2.2%) were detected. Prevalence of malaria was not affected by age and number of pregnancies (p<0.05). Microscopy and RDT, either alone ( ?=0.29; p<0.001) or in combination (?=0.33; p<0.001) showed a fair agreement with PCR. Conclusions: Our findings indicate that two doses of IPTp-SP did not protect the women against malaria in the DRC, and support the World Health Organization (WHO) guidelines that ensure a minimum of three doses of SP in pregnancy. © The Author(s) 2018. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved.
dc.identifier.citationRuh, E., Bateko, J. P., Imir, T., & Taylan-Ozkan, A. (2018). Investigation of pregnancy-associated malaria by microscopy, rapid diagnostic test and PCR in Bandundu, the Democratic Republic of Congo. Transactions of The Royal Society of Tropical Medicine and Hygiene, 112(1), 8-13.
dc.identifier.doi10.1093/trstmh/try016
dc.identifier.endpage13en_US
dc.identifier.issn0035-9203
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage8en_US
dc.identifier.urihttps://doi.org/10.1093/trstmh/try016
dc.identifier.urihttps://hdl.handle.net/11491/655
dc.identifier.volume112en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherOxford University Press
dc.relation.ispartofTransactions of the Royal Society of Tropical Medicine and Hygiene
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDemocratic Republic of Congoen_US
dc.subjectMicroscopyen_US
dc.subjectPCRen_US
dc.subjectPregnancyen_US
dc.subjectRapid Diagnostic Testen_US
dc.subjectMalariaen_US
dc.titleInvestigation of pregnancy-associated malaria by microscopy, rapid diagnostic test and PCR in Bandundu, the Democratic Republic of Congo
dc.typeArticle

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