N-methyl-D-aspartate Receptor Antagonists may Ameliorate Spinal Cord Injury by Inhibiting Oxidative Stress: An Experimental Study in Rats

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dc.contributor.authorDoğan, Güvenç
dc.contributor.authorKaraca, Onur
dc.date.accessioned2021-11-01T18:14:58Z
dc.date.available2021-11-01T18:14:58Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractAIM: To investigate the neuroprotective effect of a N-methyl-D-aspartate (NMDA) receptor antagonist (amantadine) in an experimental spinal cord injury (SCI) model. MATERIAL and METHODS: Thirty male Sprague–Dawley rats were divided into three groups: control (I), SCI (II), and SCI + amantadine (III). SCI was created using clip compression technique. At the end of day 7, blood samples were obtained from the rats and analyzed using various biochemical markers. Histological examination was also performed. MDA, GSH, and MPO assays were done. VEGF, TNF-?, and Baxexpressions were also analyzed. RESULTS: The group III had several inflammatory cells in the gray and white matter, with mildly degenerated multipolar and bipolar cells. Some bipolar and multipolar neurons showed TNF-? expression; however, TNF-? was found to be weak in small groups of inflammatory cells around the blood vessels in the substantia grisea and alba. Positive Bax expression was observed in the substantia grisea layer, particularly in the membrane of some bipolar neurons and glial cells; however, negative Bax expression was observed in neuron and glial cells and showed positive VEGF expression in the vascular endothelium in the group III. CONCLUSION: NMDA receptor antagonists, especially amantadine, may ameliorate SCI by inducing angiogenesis, affecting inflammation and apoptosis. It inhibits oxidative stress and the signaling pathways following SCI in rats.
dc.identifier.doi10.5137/1019-5149.JTN.26801-19.3
dc.identifier.endpage68en_US
dc.identifier.issn1019-5149
dc.identifier.issue1en_US
dc.identifier.pmid32091112
dc.identifier.scopus2-s2.0-85079917182
dc.identifier.scopusqualityQ3
dc.identifier.startpage60en_US
dc.identifier.urihttps://doi.org10.5137/1019-5149.JTN.26801-19.3
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpVMk5qTXpNdz09
dc.identifier.urihttps://hdl.handle.net/11491/7611
dc.identifier.volume30en_US
dc.identifier.wosWOS:000509493100009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject[No Keywords]en_US
dc.titleN-methyl-D-aspartate Receptor Antagonists may Ameliorate Spinal Cord Injury by Inhibiting Oxidative Stress: An Experimental Study in Rats
dc.typeArticle

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