Expression of CYP and GST in human normal and colon tumor tissues

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dc.authorid0000-0002-7581-1604
dc.authorid0000-0002-5892-3735
dc.authorid0000-0001-9987-0572
dc.authorid0000-0002-3689-3061
dc.authorid0000-0002-7280-4417
dc.authorid0000-0001-9210-5851
dc.contributor.authorBuluş, Hakan
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorGüler Şimşek, Gülçin
dc.contributor.authorKılıç, Murat
dc.contributor.authorAda, Ahmet Oğuz
dc.contributor.authorGöl, S.
dc.contributor.authorKaya Koçdoğan, Arzu
dc.contributor.authorKaygın, Pınar
dc.contributor.authorMoran Bozer, Büşra
dc.contributor.authorİşcan, Mehlika
dc.date.accessioned2019-05-13T08:58:54Z
dc.date.available2019-05-13T08:58:54Z
dc.date.issued2019
dc.departmentRektörlük
dc.description.abstractWe investigated the immunohistochemical staining characteristics of cytochrome P450 1A1 (CYP1A1), CYPB1, CYP2E1, and glutathione S-transferase P1 (GSTP1), GSTT1, GSTO1, GSTK1 in colon tumor and surrounding normal colon tissues. Tissues were obtained from 47 patients with colon adenocarcinoma and the staining intensity of tumor and control tissues was compared. CYP1A1, CYP1B1, CYP2E1, GSTP1, GSTT1, GSTO1 and GSTK1 expressions in colon cancer cells were significantly greater than those in normal colon epithelial cells. No significant relation was found between the isoenzyme expressions and age, gender, smoking status, tumor grade and tumor stage. The higher expressions of CYP1A1, CYP1B1, CYP2E1, GSTP1, GSTO1, GSTT1 and GSTK1 in tumor than in normal colon tissues may be important for colon cancer progression and development. © 2018, © 2018 The Biological Stain Commission.
dc.identifier.citationBulus, H., Oguztuzun, S., Güler Simsek, G., Kilic, M., Ada, A. O., Göl, S., ... & Iscan, M. (2019). Expression of CYP and GST in human normal and colon tumor tissues. Biotechnic & Histochemistry, 94(1), 1-9.
dc.identifier.doi10.1080/10520295.2018.1493220
dc.identifier.endpage9en_US
dc.identifier.issn1052-0295
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2018.1493220
dc.identifier.urihttps://hdl.handle.net/11491/1219
dc.identifier.volume94en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofBiotechnic and Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdenocarcinomaen_US
dc.subjectColonen_US
dc.subjectCytochrome P450en_US
dc.subjectGlutathione-S-Transferaseen_US
dc.subjectHumanen_US
dc.subjectSmoking Statusen_US
dc.titleExpression of CYP and GST in human normal and colon tumor tissues
dc.typeArticle

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