Angiotensin converting enzyme gene insertion/deletion variant and familial Mediterranean fever-related amyloidosis

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dc.authorid0000-0001-7639-1122
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorTürkmen, Ercan
dc.contributor.authorUzun Kaya, Süheyla
dc.contributor.authorTekcan, Akın
dc.contributor.authorSezer, Özlem
dc.contributor.authorÇelik, Sümeyya Deniz
dc.contributor.authorYiğit, Serbülent
dc.date.accessioned2019-05-13T09:07:03Z
dc.date.available2019-05-13T09:07:03Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractIntroduction. The most important complication of familial Mediterranean fever (FMF) is secondary amyloidosis, which can lead to kidney failure. Genetic variability in the genes of various components of the renin-angiotensin system may play a role in the pathogenesis of the kidney disorders. The aim of the present study was to investigate the association between angiotensin converting enzyme (ACE) gene I/D variant and risk of developing FMF-related amyloidosis in Turkish patients. Materials and Methods. A total of 240 individuals consisting of 40 patients with FMF-related amyloidosis, 100 FMF patients without amyloidosis, and 100 healthy controls were recruited. For all of the participants, ACE I/D variant was detected by the polymerase chain reaction using specific primers. Results. A significant difference was found between the patients with FMF-related amyloidosis and the control group as for genotype distribution of ACE I/D variant (P < .05). The ACE D/D and I/D genotypes were more frequent in the patients with FMF-related amyloidosis while the I/I genotype was less frequent in the same patients. The FMF patients (with and without amyloidosis) had significantly higher percentages of the D/D and I/D genotypes than the healthy controls (P < .05). Comparison between the subgroups of FMF patients, divided into those with and without amyloidosis, yielded a significant correlation according to ID+II versus DD genotypes (P < .03, odds ratio, 3.24; 95% confidence interval, 1.05 to 12.01). Conclusions. Based on these observations, the ACE I/D variant D/D genotypes implicate a possible risk in the FMF-related amyloidosis among Turkish population. © 2018, Iranian Society of Nephrology. All rights reserved.
dc.identifier.citationNursal, A. F., Turkmen, E., Kaya, S. U., Tekcan, A., Sezer, Ö., Çelik, S. D., Yiğit, S. (2018). Angiotensin converting enzyme gene insertion/deletion variant and familial Mediterranean fever-related amyloidosis. Iranian Journal of Kidney Diseases, 12(3), 150.
dc.identifier.endpage155en_US
dc.identifier.issn1735-8582
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage150en_US
dc.identifier.urihttps://hdl.handle.net/11491/1711
dc.identifier.volume12en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIranian Society of Nephrology
dc.relation.ispartofIranian Journal of Kidney Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAngiotensin-Converting Enzymeen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectSecondary Amyloidosisen_US
dc.titleAngiotensin converting enzyme gene insertion/deletion variant and familial Mediterranean fever-related amyloidosis
dc.typeArticle

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