Serum ADMA, endothelial dysfunction, and atherosclerosis in hypervolemic hemodialysis patients

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dc.authorid0000-0002-3922-4517
dc.contributor.authorDoğan, İbrahim
dc.contributor.authorEser, Barış
dc.contributor.authorÖzkurt, Sultan
dc.contributor.authorYayar, Özlem
dc.contributor.authorÖzgür, Bülent
dc.contributor.authorKayadibi, Hüseyin
dc.contributor.authorDoğan, Tolga
dc.contributor.authorMusmul, Ahmet
dc.contributor.authorSoydan, Mehmet
dc.date.accessioned2019-05-13T09:02:44Z
dc.date.available2019-05-13T09:02:44Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground/aim: Asymmetric dimethyl arginine (ADMA) is a strong predictor of cardiovascular disease and mortality in patients under hemodialysis treatment. We aimed to investigate the relationship among volume status, endothelial dysfunction, and ADMA in hemodialysis patients. Materials and methods: A total of 120 patients with a history of hemodialysis treatment were included. ADMA and CRP were measured. Echocardiographic evaluation and carotid artery intima–media thickness (CIMT) measurements were performed. Patients were divided into two groups according to clinical evaluation, ultrafiltration rate, vena cava inferior diameter (VCI), and cardiothoracic index (CTI); the two groups were hypervolemic and normovolemic. Results: The hypervolemic group included 61 patients while the normovolemic group included 59 patients. CIMT was higher in the hypervolemic group, but this result was not statistically significant (0.95 mm versus 0.85 mm, P = 0.232). There was a statistically significant difference between the hypervolemic and normovolemic groups in terms of ADMA (P < 0.001) (0.69 ± 0.57 µmol/L and 0.41 ± 0.04 µmol/L, respectively). Positive correlations were observed between serum ADMA, VCI, CTI, CRP, CIMT, and cardiac mass (P < 0.001, P = 0.016, P < 0.001, P = 0.006, P = 0.022, respectively), and negative correlations were observed between ADMA and ejection fraction and albumin (P = 0.024, P = 0.024, respectively). In multiple linear regression analysis, ADMA was independently associated with age, systolic blood pressure, CTI, and volume status. Conclusion: ADMA may be a potential determinant of hypervolemia as well as atherosclerosis in patients under hemodialysis treatment. © TÜBİTAK.
dc.identifier.citationDoğan, İ., Eser, B., Özkurt, S., Yayar, Ö., Özgür, B., Kayadibi, H., Doğan, T., Muşmul, A., Soydan, M. (2018). Serum ADMA, endothelial dysfunction, and atherosclerosis in hypervolemic hemodialysis patients. Turkish Journal of Medical Sciences, 48(5), 1041-1047.
dc.identifier.doi10.3906/sag-1804-98
dc.identifier.endpage1047en_US
dc.identifier.issn1300-0144
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1041en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1804-98
dc.identifier.urihttps://hdl.handle.net/11491/1318
dc.identifier.volume48en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTÜBİTAK
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed*
dc.subjectAsymmetric Dimethyl Arginineen_US
dc.subjectAtherosclerosisen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectHemodialysisen_US
dc.subjectHypervolemiaen_US
dc.titleSerum ADMA, endothelial dysfunction, and atherosclerosis in hypervolemic hemodialysis patients
dc.typeArticle

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