Analysis of MMP-7 and TIMP-2 gene polymorphisms in coronary artery disease and myocardial infarction: A Turkish case-control study

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dc.authorid0000-0002-4368-0777
dc.contributor.authorAlp, Ebru
dc.contributor.authorYılmaz, Akın
dc.contributor.authorTulmaç, Murat
dc.contributor.authorUğraş Dikmen, Asiye
dc.contributor.authorÇengel, Atiye
dc.contributor.authorYalçın, Rıdvan
dc.contributor.authorMenevşe, Emine Sevda
dc.date.accessioned2019-05-13T09:08:44Z
dc.date.available2019-05-13T09:08:44Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractMatrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinase (TIMP) have a significant role in tissue remodeling related to cardiac function. In earlier studies, MMP-7 A-181G (rs11568818), C-153T (rs11568819), C-115T (rs17886546), and TIMP-2 G-418C (rs8179090) polymorphisms have been studied in various diseases. However, association between coronary artery disease (CAD) and these polymorphisms has been poorly studied. The goal of this study is to investigate the association of CAD and myocardial infarction (MI) with MMP-7 or TIMP-2 polymorphisms. This study included 122 CAD patients and 132 control individuals. DNA was extracted from whole blood. Polymerase chain reaction-restriction fragment length polymorphism and automated direct sequencing method were used for genotyping of these polymorphisms. No significant differences were found between MMP-7 A-181G, C-115T, and TIMP-2 G-418C polymorphism and CAD or MI in a Turkish population. Despite the fact that the genotypes of MMP-7 C-153T polymorphism had no significant differences among MI and control groups, allele frequencies of C-153T polymorphism were significantly different between the two groups. Our study is the first report to clarify the appreciable relationship between MMP-7 C-153T polymorphism and MI development in CAD patients. However, these findings also need to be confirmed in other populations so we can improve our knowledge about the genetic factors affecting the development of CAD. © 2017
dc.identifier.citationAlp, E., Yılmaz, A., Tulmaç, M., Uğraş Dikmen, A., Çengel, A., Yalçın, R., Menevşe, E. S. (2017). Analysis of MMP-7 and TIMP-2 gene polymorphisms in coronary artery disease and myocardial infarction: A Turkish case-control study. The Kaohsiung Journal of Medical Sciences, 33(2), 78-85.
dc.identifier.doi10.1016/j.kjms.2016.12.002
dc.identifier.endpage85en_US
dc.identifier.issn1607-551X
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage78en_US
dc.identifier.urihttps://doi.org/10.1016/j.kjms.2016.12.002
dc.identifier.urihttps://hdl.handle.net/11491/2043
dc.identifier.volume33en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier (Singapore) Pte Ltd
dc.relation.ispartofKaohsiung Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCoronary Artery Diseaseen_US
dc.subjectMMP-7en_US
dc.subjectMyocardial Infarctionen_US
dc.subjectPolymorphismen_US
dc.subjectTIMP-2en_US
dc.titleAnalysis of MMP-7 and TIMP-2 gene polymorphisms in coronary artery disease and myocardial infarction: A Turkish case-control study
dc.typeArticle

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