Antioxidant role of melatonin against nicotine’s teratogenic effects on embryonic bone development

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dc.contributor.authorYılmaz, Halil
dc.contributor.authorErtekin, Tolga
dc.contributor.authorAtay, Emre
dc.contributor.authorNisari, Mehtap
dc.contributor.authorSusar Güler, Hatice
dc.contributor.authorAl, Özge
dc.contributor.authorPayas, Ahmet
dc.contributor.authorYılmaz, Seher
dc.date.accessioned2019-05-13T09:07:25Z
dc.date.available2019-05-13T09:07:25Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Sungurlu Meslek Yüksekokulu, Terapi ve Rehabilitasyon Bölümü
dc.description.abstractObjective(s): This study investigated the possible effects of low (3 mg/kg) and high (6 mg/kg) doses of nicotine on the skeletal development of rat fetuses by the double staining method and the protective role of melatonin (10 mg/kg) against these effects. Materials and Methods: Eighteen adult female Wistar-Albino rats were divided into six groups (n=3, each) as control, low-dose nicotine, high-dose nicotine, low-dose nicotine+melatonin, high-dose nicotine + melatonin and melatonin. While nicotine was given to the experimental groups on gestation days 1–20, nicotine and melatonin were administered together to the treatment groups. The fetuses were delivered by cesarean section on the 20th day of pregnancy. The skeletal systems of the fetuses were stained using the double staining method. The forelimbs and hindlimbs of the fetuses were firstly investigated under a stereomicroscope, and then their photos were taken. The total bone length, the length of the ossified part and the ossification rate were calculated using the ImageJ program. Results: The degree of ossification in the bones of the feet and the hands was determined. When the total bone length and the length of the ossified part were evaluated, they were significantly decreased in the nicotine groups (P<0.05), but were close to each other in the treatment and the control groups (P<0.05). Conclusion: It has been found that the use of nicotine during pregnancy delays skeletal ossification and that melatonin, a powerful antioxidant, eliminates the teratogenic effects of nicotine. © 2018, Mashhad University of Medical Sciences. All rights reserved.
dc.identifier.citationYılmaz, H., Ertekin, T., Atay, E., Nisari, M., Susar Güler, H., Al, Ö., Payas, A., Yılmaz, S. (2018). Antioxidant role of melatonin against nicotine’s teratogenic effects on embryonic bone development. Iranian Journal of Basic Medical Sciences, 21, 787-793.
dc.identifier.doi10.22038/ijbms.2018.26705.6539
dc.identifier.endpage793en_US
dc.identifier.issn2008-3866
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage787en_US
dc.identifier.urihttps://doi.org/10.22038/ijbms.2018.26705.6539
dc.identifier.urihttps://hdl.handle.net/11491/1798
dc.identifier.volume21en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMashhad University of Medical Sciences
dc.relation.ispartofIranian Journal of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBoneen_US
dc.subjectMelatoninen_US
dc.subjectNicotineen_US
dc.subjectOssificationen_US
dc.subjectRaten_US
dc.titleAntioxidant role of melatonin against nicotine’s teratogenic effects on embryonic bone development
dc.typeArticle

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